To explore the therapeutic effect of Wuling Capsules（乌灵胶囊）combined with Shenqi Wuweizi Tablets（参芪五味子片）on elderly patients with stable angina pectoris and anxiety and depression.

A total of 126 elderly patients with stable angina pectoris combined with anxiety and depression admitted to the cardiology department of the hospital from February 2022 to February 2023 were selected and randomly divided into experimental group and control group，with 63 cases in each group. The control group patients received Western medicine treatment，including Bisoprolol Fumarate Tablets，Xinkang Sustained-Release Tablets and Aspirin Enteric Coated Tablets. On the basis of the control group，the experimental group received Wuling Capsules combined with Shenqi Wuweizi Tablets. The efficacy of stable angina pectoris，electrocardiogram efficacy，traditional Chinese medicine syndrome efficacy，the scores of anxiety and depression，the sleep quality score，the levels of plasma atrial natriuretic peptide（ANP），endothelin（ET），cholesterol（TC），triacylglycerol（TG），norepinephrine（NE），5-hydroxytryptamine（5-HT）and dopamine（DA）and the occurrence of adverse reactions of two groups were compared.

Compared with that of the control group，the treatment effect of stable angina pectoris in the experimental group was better（P<0.05）. Compared with those before treatment，the self-rating anxiety scale（SAS），self-rating depression scale（SDS）and Pittsburgh sleep quality index（PSQI）scores of the two groups decreased after treatment. Compared with the control group，the SAS，SDSand PSQI scores of the experimental group were lower after treatment（P<0.05）. After treatment，compared with those before treatment，the levels of ANP，ET，TCand TG in the two groups decreased. After treatment，compared with the control group，the experimental group had lower levels of ANP，ET，TCand TG，with statistically significant differences（P<0.05）. Compared with those before treatment，the levels of NE，5-HT and DA in the two groups increased after treatment. Compared with the control group，the experimental group had higher levels of NE，5-HT and DA after treatment（P<0.05）. There was no difference in the occurrence of adverse reactions between the two groups（P>0.05）.

Wuling Capsules combined with Shenqi Wuweizi Tablets can improve the symptoms of angina pectoris in elderly patients with stable angina pectoris and anxiety，alleviate negative emotions such as anxiety and depression and down-regulate the levels of ANP，ET，TC，TG and monoamine neurotransmitters，making it suitable for clinical application.