To observe the effect of Buyang Huanwu Decoction（补阳还五汤）on vascular revascularization rate and other indexes in patients with acute cerebral infarction after mechanical thrombectomy.

A total of 60 patients with acute cerebral infarction admitted to the Department of Neurology and Emergency Department of the hospital from June 2022 to June 2023 were selected as the research objects. According to the random number table method，the patients were evenly divided into control group and observation group，with 30 cases in each group. The patients in the control group received instrument thrombectomy treatment，and those in the observation group were treated with Buyang Huanwu Decoction on the basis of the control group. The clinical effect，coagulation index，prognosis，nerve function，vascular recanalization and adverse events of the two groups were observed.

The effective rate of the control group was 66.67%，and that of the observation group was 90.00%，which was significantly higher than that of the control group（P<0.05）. The vascular recirculation rate（m-TICIlevel 2b or 3）of the control group was 66.67%，and that of the observation group was 73.33%，with no significant statistical significance between the two groups（P>0.05）. Before treatment，there was no significant difference in National Institute of Health stroke scale（NIHSS）score between the two groups（P>0.05）. Compared with those before treatment，NIHSSscores in both groups were significantly lower at 24 hours and 3 months after treatment（P<0.01）. Compared with those in the control group，the NIHSSscores in the observation group were significantly lower at 24 hours and 3 months after treatment（P<0.01）. Before treatment，there were no significant differences in coagulation indexes such as platelet count（PLT），D-dimer（D-D），activated partial thromboplastin time（APTT），prothrombin time（PT），thrombin time（TT）or international normalized ratio（INR）between two groups（P>0.05）. After the intervention，the levels of PLT，D-D，APTT and PT in the observation group were significantly reduced compared with those in the control group，and the differences were statistically significant（P<0.01，P<0.05）. The good prognosis rate of mRSin the control group and the observation group at 3 months was 43.33% and 70.00%，respectively. Compared with that in the control group，the good prognosis rate in the observation group was significantly increased（P<0.05）. During treatment，the main adverse events of the two groups were oral，cutaneous mucous and digestive tract hemorrhage and liver and kidney damage. The total incidence of adverse events in the control group and the observation group was 13.33% and 20.00% respectively，with no statistical significance（P>0.05）.

Buyang Huanwu Decoction combined with mechanical thrombectomy can better improve the nerve function，coagulation index and prognosis of patients with acute cerebral infarction，which is suitable for popularization.