Hepatocellular carcinoma(HCC)has a high degree of malignancy and poor prognosis,and the current treatment methods have not achieved ideal efficacy. HCCbelongs to the categories of “jaundice”,“accumulation”,“abdominal mass” and “tympania” in traditional Chinese medicine(TCM),and TCM syndrome differentiation and treatment has unique advantages in treatment on HCC. As the core of TCM compound,the research value of Chinese drug pair is of great significance to clinical drug guidance. Studies have found that some drug pairs can relieve clinical symptoms such as abdominal pain,bloating,fatigue and poor appetite,reduce TCM symptom scores,and improve patients'quality of life and prognosis. Pharmacological studies have found that the drug pair has a synergistic and detoxifying effect after combination,and can treat HCCby inhibiting tumor cell proliferation,invasion and migration,blocking cell cycle,and inducing apoptosis and other multi-target ways. Therefore,this paper summarized the efficacy,pharmacological research and clinical application of some “drug pairs” in the treatment of HCC,in order to provide a theoretical basis for the “drug pairs” in the treatment of HCC and provide clinical reference for the prevention and treatment of HCC by TCM.
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |