Full
Outline
By studying the anti-aging effect of Cistanche deserticola polysaccharides（CDPS）in vivo，it aimed to explore the possible mechanisms underlying this anti-aging effect.
Seventy-five Kunming species（KM）mice aged 12 months were randomly divided into a blank control group（WT），a low-dose group of Cistanche deserticola polysaccharides（CDPS. L），a medium dose group of Cistanche deserticola polysaccharides（CDPS. M），a high-dose group of Cistanche deserticola polysaccharides（CDPS. H），and a positive drug group（P）. The mice were given corresponding drugs or the same volume of distilled water by gavage until obvious signs of death appeared. The other mice that did not show obvious signs of death were uniformly sampled 180 days after administration. The levels of glutathione peroxidase（GSH-Px），total superoxide dismutase（TSOD）and malondialdehyde（MDA）in serum were detected to observe the antioxidant effect of Cistanche deserticola polysaccharides.16SrRNA sequencing was used to analyze the structure of gut microbiota. The effects on cognitive ability and intestinal function of mice were observed through HE staining of pathological sections of the hippocampus and intestines.
Compared with that o the WT group，the survival rate of the mice treated with CDPSwas improved，and the effect of CDPS. M and CDPS. H groups was better than that of Pgroup，but it was not significant. Compared with those of the WT group mice，the GSH-Px activity and T-SOD activity of the CDPSgroups were significantly increased，and the MDA levels in each treatment group were significantly reduced compared to that in the WT group，and the GSH-Px activity of CDPS. H group was significantly improved compared to that in Pgroup. CDPScan improve the intestinal microbiota homeostasis in mice，increase the levels of Akkermansia muciniphila，Alloprevotella and Prevotellaceae probiotics，and improve intestinal function. Compared with those of the other groups，the intestinal villus length and wall thickness of mice were longer. CDPSalso can reduce hippocampal neuronal death caused by aging.
CDPShas anti-aging effects，which may be due to its antioxidant properties and its ability to improve intestinal function，thereby affecting the homeostasis of gut microbiota，resulting in an increase in the levels of Akkermansia muciniphila，Alloprevotella and Prevotellaceae probiotics. Additionally，the effect of CDPSon reducing hippocampal neuronal death in mice may also be one of the anti-aging mechanisms of CDPS.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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