To explore the effectof Chaihu Qingshang Decoction(柴胡清上汤)combined with gaze stability vestibular rehabilitation training on vestibular function and oxidative stress in patients with vestibular neuritis.
Sixty patients with vestibular neuritis who were diagnosed in the hospital from July 2021 to December 2022 were selected as research objects,and were randomly divided into the experimentgroup and the control group,with 30 patients in each group. The control group was given routine and symptomatic treatment,and the experiment group was given Chaihu Qingshang Decoction combined with gaze stability vestibular rehabilitation training on the basis of the control group. The clinical efficacy,dizziness symptom assessment scale,dizziness disorder scale,specific activity balance confidence scale,vestibular function,serum inflammatory factors,oxidative stress indicators and incidence of adverse reactions were compared between the two groups before and after treatment.
After treatment,compared with the total effective rate(63.33%,19/30)in the control group,the total effective rate(86.67%,26/30)in the experimental group was higher(P<0.05). Compared with those before treatment,the Vertigo Symptom Rating Scale(DARS)and Dizziness Handicap Inventory(DHI)scores of both groups were significantly reduced,while the activities-specific balance confidence scale(ABC)scores were increased(P<0.05). After treatment,compared with the control group,the experimental group had lower DARSand DHIscores,and higher ABC scores(P<0.05). Compared with that before treatment,semicircular canal paresis(CP)value,scanning wave amplitude,spontaneous nystagmus intensity and shaking head nystagmus intensity of semicircular canals paresis patients in the two groups decreased significantly,and semicircular canals gain increased significantly(P<0.05). After treatment,compared with those of the control group,the CP value,scanningwave amplitude,spontaneous nystagmus intensity and shaking head nystagmus intensity of semicircular canals paresis in the experiment group were lower,and the semicircular canals gain was higher(P<0.05). Compared with those before treatment,the serum levels of IL-6 and TNF-αin both groups significantly decreased(P<0.05). And compared with those of the control group,the levels of the experimental group were relatively low(P<0.05). Compared with those before treatment,the levels of SOD in both groups significantly increased,while the levels of MDA decreased(P<0.05). Compared with the control group,the experimental group had higher level of SOD and lower level of MDA(P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).
Chaihu Qingshang Decoction combined with gaze stability vestibular rehabilitation training can effectively improve the overall therapeutic effect of patients with vestibular neuritis,regulate inflammation and oxidative stress in the body,significantly improve vestibular function,alleviate nystagmus and semicircular canals paresis,which is suitable for clinical promotion.
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |