To evaluate the regulatory effectof Tiaozhong Xiaqi Decoction（调中下气汤）combined with gastricmucosa protectant on serum gastrin in patients with chronic atrophic gastritis.

A total of 112 patients with chronic atrophic gastritis who came to the hospitalwere selected as the study subjects. According to the randomized control method，the invalids were divided into two groups. The reference group（56 cases）was treated with conventional Western medicine，orally taking Weifuchun Tablets（胃复春片），4 tablets per time，3 times per day. The Helicobacter pylori（HP）positive individuals were treated with HP eradication regimen and quadruple therapy for 10 days. On the basis of treatment in the reference group，the study group（56 cases）received Tiaozhong Xiaqi Decoction orally. Both groups continued the treatment for 3 months. The changes in traditional Chinese medicine syndrome scores，including cold pain in the stomach，bloating in the stomach，liking warmth and pressing，vomiting with clear water，shortness of breath，lazy speech and loose stools before and after treatment between two groups were compared. The changes in pathological scores under gastroscopy between the two groups before and after treatment were compared，and the changes in serum levels of gastrin（GAS），somatostatin（SS）and epidermal growth factor（EGF）and treatment efficacy before and after treatment were compared.

The treatment efficacy of the study group was better than thatof the reference group，and the difference was statistically obvious（P<0.05）. After treatment，the scores of spleen and stomach deficiency cold syndrome related symptoms in both groups showed a decrease，and the reduction in scores of spleen and stomach deficiency cold syndrome related symptoms in the study group was better than that in the reference group（P<0.05）. After treatment，both groups showed a decrease in pathological scores under gastroscopy，and the reduction in pathological scores under gastroscopy in the the study group was better than that in the control group（P<0.05）. After treatment，the levels of GAS in both groups decreased，while the levels of SSand EGF increased. Among them，the study group had a better decrease in serum GAS than the reference group，while the increase in SSand EGFwas better than that in the reference group（P<0.05）.

Tiaozhong Xiaqi Decoction combined with gastric mucosa protector is effective in the treatment of chronic atrophic gastritis. It can reduce the TCM symptom scores of patients，alleviate the atrophic state of gastric mucosa，regulate gastrointestinal hormones，inhibit the excessive secretion of gastrin，protect gastric mucosa tissue，accelerate the recovery of gastric function and improve the treatment effect.