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Research Progress on Treatment of Alzheimer's Disease with Traditional Chinese Medicine Targeting PI3K/Akt Signaling Pathway
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Jiaxin LI, Shaofeng WANG, Yanwei HAO, Xueqing DUAN, Li LI, Bin LI
Chinese Archives of Traditional Chinese Medicine | 2025, 43(1) : 72 - 76
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Chinese Archives of Traditional Chinese Medicine | 2025, 43(1): 72-76
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Research Progress on Treatment of Alzheimer's Disease with Traditional Chinese Medicine Targeting PI3K/Akt Signaling Pathway
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Jiaxin LI, Shaofeng WANG, Yanwei HAO, Xueqing DUAN, Li LI, Bin LI
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  • Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan, China
Published: 2025-01-10 doi: 10.13193/j.issn.1673-7717.2025.01.014
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Alzheimer's disease is the most common type of dementia，characterized by cognitive decline and memory dysfunction. The orderly operation of cellular signal transduction pathways in the brain maintains the physiological function and activity of nerve cells. The phosphatidylinositol-3 kinase/protein kinase B（PI3K/Akt）signaling pathway is a classical pathway for cell proliferation，differentiation，growth and apoptosis，which can regulate downstream effector molecules involved in the occurrence and development of Alzheimer's disease. Itplays an important role in various aspects such as abnormal protein aggregation，insulin resistance in the brain，neuroinflammation，oxidative stress，apoptosis and atophagy. Based on the current research status at home and abroad，the article reviewed and summarized the recent progress in traditional Chinese medicine treating Alzheimer's disease by regulating the PI3K/Akt signaling pathway in recent years in order to provide new ideas for Alzheimer's disease drug treatment and provide reference for further in-depth mechanism research.

PI3K/Akt signaling pathway  /  Alzheimer's disease  /  traditional Chinese medicine  /  research progress
李佳欣, 王少锋, 郝彦伟, 段学庆, 李莉, 李斌. 中药靶向PI3K/Akt信号通路治疗阿尔茨海默病的研究进展. 中华中医药学刊, 2025 , 43 (1) : 72 -76 . DOI: 10.13193/j.issn.1673-7717.2025.01.014
Jiaxin LI, Shaofeng WANG, Yanwei HAO, Xueqing DUAN, Li LI, Bin LI. Research Progress on Treatment of Alzheimer's Disease with Traditional Chinese Medicine Targeting PI3K/Akt Signaling Pathway[J]. Chinese Archives of Traditional Chinese Medicine, 2025 , 43 (1) : 72 -76 . DOI: 10.13193/j.issn.1673-7717.2025.01.014
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Year 2025 volume 43 Issue 1
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doi: 10.13193/j.issn.1673-7717.2025.01.014
  • Online Date：2026-10-30
  • Published：2025-01-10
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    Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan, China
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