To systematically review the willingness to use pre-exposure prophylaxis (PrEP) and related factors among men who have sex with men (MSM) in China.

CNKI, VIP, Wanfang Data, CBM, EMbase, CINAHL, Pubmed, The Cochrane Library and Web of Science were searched from inception to August 16, 2023.

A total of 31 articles with 31 390 participants were included. The results of meta-analysis showed that the awareness rate of PrEP was 46.70% (95% CI: 34.14-59.47), the willingness rate of PrEP use was 61.49% (95% CI: 51.58-70.95), and the use rate of PrEP was 3.41% (95% CI:0.07-10.62). Age≥40 years (OR=1.90, 95% CI:1.47-2.57), HIV testing history (OR=2.13, 95% CI:1.63-2.80), awareness of PrEP (OR=2.80, 95% CI:1.86-4.24), online sexual partner seeking (OR=1.44, 95% CI:1.04-2.00), no regular sexual partner (OR=1.69, 95% CI:1.32-2.17), oral sex/anal sex behavior (OR=1.86, 95% CI:1.32-2.61), number of homosexual anal sex partners in the past 6 months>5 (OR=1.86，95% CI:1.32-2.61), Having oral or anal sex in the past year (OR=1.40，95% CI:1.19-1.65) was the promoting factor of PrEP use, while uncertain sexual orientation (OR=0.60, 95% CI:0.41-0.89) and always using condom in the past 6 months (OR=0.47, 95% CI:0.29-0.75) were the barriers.

The rate of MSM PrEP awareness and willingness to use is high in China, but the rate of PrEP use is low; more factors influence the willingness to use PrEP.

To understand the impact and pathways of lifestyle behaviors on physiological sub-health of medical students, and to provide a basis for health management and health education in universities.

Under the use of stratified whole cluster random sampling method, 3 100 medical students from a medical university were selected as the study subjects, general situation questionnaire, lifestyle factor questionnaire and Sub-Health Measurement Scale Version 1.0 (SHMS V1.0) were used for questionnaire survey. Chi-square test, exploratory factor analysis and structural equation model were used for statistical analysis and path construction.

The total detection rate of medical students’ sub-health status was 62.2%. There were significant differences in the distribution of drinking (χ²=12.245,P<0.001), activity(Frequency of exercise(χ²=46.115, P<0.001);Frequency of activities between classes(χ²=7.179,P=0.028);Leisure promotes health(χ²=60.789,P<0.001)), dietary habits (Frequency of takeout orders(χ²=8.912, P=0.012);Frequency of consumption of sugar-sweetened beverages(χ²=23.437,P<0.001);Bad eating habits(χ²=82.863,P<0.001))and mobile phone and computer usage(Time spent on mobile phones and computers(χ²=12.350, P=0.002); Short video viewing time(χ²=9.291,P=0.026)) among medical students with different physiological health states. The direct effect of activity on physiological sub-health of medical students was 0.26(95% CI:0.137-0.366). The direct effect of dietary habits on physiological sub-health of medical students was -0.171 (95% CI:-0.233--0.035), and the indirect effect was -0.04(95% CI:-0.085--0.015). The indirect effect of mobile phone and computer usage on physiological sub-health of medical students was -0.043 (95% CI: -0.087--0.017).

The overall detection rate of sub-health status among medical students is relatively high. Physical activity is a significant influencing factor in the physiological sub-health status of medical students and serves as a mediator between dietary habits and mobile phone and computer usage with respect to the physiological sub-health status of medical students.

To analyze the effects of diabetes distress (DD) and depressive symptoms (DS) on self-efficacy in community patients with type 2 diabetes mellitus (T2DM), and to explore the mediating effect of DD on DS and self-efficacy.

A total of 648 community patients with T2DM in Nanjing were selected by convenience sampling method and investigated with the general information questionnaire, Diabetes Distress Scale, 9-item Patient Health Questionnaire and Diabetes self-efficacy Scale. A multiple linear regression model was used to analyze the influencing factors of self-efficacy, and mediating effect analysis was used to explore the mediating role of DD.

The prevalence of DD and DS was 27.5% and 40.4%, respectively, and the self-efficacy score was 3.82±0.60. DD and DS were significantly positively correlated (r=0.56, P<0.01), and both were negatively correlated with self-efficacy. DD (β=-0.34, P<0.01) and DS (β=-0.16, P<0.01) were the influencing factors of self-efficacy, and DD had a partial mediating effect between DS and self-efficacy, Bootstrap 95%confidence interval was -0.28--0.16 (P<0.01).

Community health workers need to conduct early screening and treatment of DD and DS in T2DM patients, which can help improve patients’ self-efficacy inmanaging the disease.

To evaluate the relationship between dietary diversity and hypertension among residents aged 35-74 in the Guangxi Province, to analyze the association between dietary diversity and hypertension by assessing the Dietary Diversity Score (DDS), and to provide reference for improving dietary diversity and controlling hypertension in the local population.

This cross-sectional study included participants from the Prospective Cohort Study on Chronic Diseases in Guangxi Ethnic Minority Population. Baseline surveys and physical measurements were conducted on residents aged 35-74. A dietary diversity score (DDS) was calculated based on a food frequency questionnaire. Binary logistic regression models were used to explore the relationship between DDS and hypertension, and restricted cubic spline models were used to examine the dose-response relationship between DDS and hypertension.

A total of 12 896 participants were included, among whom 4541 (35.21%) were diagnosed with hypertension. The mean DDS of residents aged 35-74 in Guangxi was (5.45±1.39). The consumption frequency of cereals and tubers was high, while the intake of dairy products was relatively low. The binary logistic regression analysis showed that after adjusting for confounding factors, DDS was a protective factor for hypertension (OR=0.95, 95% CI: 0.92-0.98, P=0.001). The restricted cubic spline model demonstrated a linear dose-response relationship between DDS and hypertension (P_{overall trend}<0.05, P_{non-linearity}=0.787). As DDS increased, the risk of hypertension linearly decreased.

The prevalence of hypertension is high among residents aged 35-74 in the Guangxi Province, while the level of dietary diversity is relatively low. Increasing dietary diversity may help reduce the incidence of hypertension.

To investigate the causal relationship between gut microbiota and insomnia by two-sample Mendelian randomization analysis.

The summary statistics of gut microbiota came from a meta-analysis of the largest genomewide association study conducted by the MiBioGen Alliance. The summary statistics for insomnia came from the genomewide association study of insomnia measurement. Inverse variance weighted, MR-Egger, weighted median, simple mode method, and weighted mode method were used to study the causal relationship between gut microbiota and insomnia. The stability of the results was evaluated by a series of sensitivity analyses.

MR analysis showed that soft membrane Mollicutes RF9 [β=-0.86, OR(95%CI): 0.42(0.25-0.71)] and unknown family [β=-0.86, OR(95%CI): 0.42(0.25-0.71)] had protective effect on insomnia. In addition, 14 other groups were found to be potentially causally associated with insomnia in this study including Oxalobacteraceae (F=170.153, P=0.034), Marvinbryantia (F=162.702, P=0.006), Ruminococcaceae UCG002 (F=298.323, P=0.046), Subdoligranulum (F=198.442, P=0.045), Anaerostipes (F=222.074, P=0.032), Gammaproteobacteria (F=91.816, P= 0.006) , Pasteurellales (F=231.141, P=0.010), Lachnospiraceae UCG010 (F=138.761, P=0.045), Peptococcus (F=287.210, P=0.036), Ruminococcus gnavus group (F=162.913, P=0.031), Dorea (F=112.086, P=0.049), Flavonifractor (F=95.307, P=0.020), and unknown genus(F=89.189, P=0.001). No significant heterogeneity or pleiotropy was detected.

Mendelian randomization shows that the flexurales, unknown families, and 14 other taxa are causally related to insomnia. The gut microbiota may be one of the treatments to improve insomnia.

To understand the current situation and characteristics of chronic disease comorbidities among the elderly living alone in China, to analyze their comorbidity patterns, and to explore the relationship between health-related behaviors and chronic comorbidity in the elderly living alone, so as to provide basis for co-prevention and co-management of multiple diseases in the elderly.

Based on the data of the 2018 Chinese longitudinal healthy longevity survey (CLHLS), the network map was used to identify the common binary co-disease patterns of chronic diseases in the elderly living alone, and the Gephi software was used to visualize the chronic disease co-disease network of the elderly. Using Apriorism algorithm, the association rules were used to analyze the correlation between health-related behaviors and co-diseases of the elderly living alone, and multi-factor Logistic regression model was used to analyze the correlation between chronic diseases and health-related behaviors of the elderly living alone.

A total of 1 905 elderly people living alone over 65 years were included, of whom 766 suffered from two or more chronic diseases, and the co-morbidity of chronic diseases was 40.2%. A total of 45 meaningful binary co-disease patterns with strong links were identified through network map analysis, of which 10 were related to hypertension and 7 were related to heart disease. The strong association rules among the association rules of health-related behaviors and co-diseases of the elderly living alone were poor sleep quality, no physical activity, no exercise, and no outdoor activity. The multivariate Logistic regression model showed that the elderly living alone with smoking (OR=1.791, 95%CI: 1.205-2.664) and alcohol consumption (OR=1.597, 95%CI: 1.084-2.353) had an increased risk of chronic co-disease compared with those without chronic diseases. Elderly people living alone with exercise (OR=0.132, 95%CI: 0.100-0.175), outdoor activities (OR=0.047,95%CI: 0.035-0.063), good sleep quality (OR=0.469, 95%CI: 0.319-0.688), and adequate sleep (OR=0.648, 95%CI: 0.484-0.867) had a lower risk of chronic comorbidity.

The comorbidity pattern of the elderly living alone in China is complex and related to health-related behaviors. The risk of comorbidity in the elderly can be reduced by improving health-related behaviors, such as increasing exercise and outdoor activities and adjusting sleep duration and sleep quality.

To analyze the coupling and coordination relationship between the supply of medical resources and the utilization of medical services in Chengdu-Chongqing economic circle from 2016 to 2021, so as to provide reference for optimizing the allocation of medical resources.

Based on the comprehensive evaluation index system of medical resources supply and service utilization, a comprehensive evaluation model and a coupling coordination degree model were constructed to analyze the coupling and coordination relationship between medical resources supply and service utilization in Chengdu-Chongqing economic circle from 2016 to 2021. With the use of exploratory spatial data analysis, the spatial-temporal evolution characteristics of medical resources coupling coordination were analyzed.

From 2016 to 2021, the development levels of medical resources supply and service utilization in Chengdu-Chongqing economic circle were 0.11-0.13 and 0.14-0.15, respectively, and the relative degree of development changed from shortage of medical resources (0.78) to mutual complement and promotion of development (0.92). However, the proportion of cities subject to lagging supply of medical resources was still large (68.8% in 2021). The level of coupling coordination changed from 0.47 to barely coordinated development. By 2021, only Chongqing and Chengdu had a good coordinated development. The LISA diagram showed that the “high-high” areas increased year by year, and the “cold point” effect disappeared, but there was still a “highland” phenomenon centered on Nanchong.

The development level of medical resource supply and service utilization in Chengdu-Chongqing economic circle is stable and rising, but the overall level is low and the regional gap is obvious. The coupling coordination level needs to be further improved, which is mainly limited by the lagging supply of medical resources. The spatial positive correlation of coupling coordination degree is gradually enhanced, but the spatial heterogeneity is still prominent.

To analyze the status of non-response to hepatitis B vaccine and its related factors in children born to mothers infected with hepatitis B virus (HBV).

The children born to mothers with HBV infection reported in Hunan Province from January to December 2022 were selected. All the children received hepatitis B immunoglobulin injection and 3 doses of hepatitis B vaccination and were followed up to 7-12 months of age for detection of hepatitis B surface antigen (HBsAg) and anti-HBs. Both HBsAg and anti-HBs were negative, indicating that there was no response to hepatitis B vaccine in children. Unconditional binary logistic regression model was used to analyze the related factors of non-response to hepatitis B vaccine in children.

A total of 9 792 children born to mothers infected with HBV were analyzed. Among 9 792 children, the non-response rate of hepatitis B vaccine was 9.5% (928/9 792). Non-conditional binary Logistic regression analysis showed that the risk of non-response to hepatitis B vaccine in children born to HBeAg-positive mothers was 1.62 times higher than that in children born to HBeAg-negative mothers (OR=1.62, 95%CI: 1.40-1.88). The risk of non-response to hepatitis B vaccine in children with macrosomia (birth weight ≥ 4 000g) was 1.41 times higher than that in children with normal birth weight (OR=1.41, 95%CI: 1.08-1.85). Maternal antiviral therapy (OR=0.59, 95%CI: 0.48-0.73) and child HepB standard vaccination (OR=0.66, 95%CI: 0.57-0.78) were the protective factors of non-response to hepatitis B vaccine in children.

The non-response rate of hepatitis B vaccine in children born to HBV infected mothers is high, and it is affected by maternal HBeAg positive, antiviral therapy during pregnancy, birth weight, and standard vaccination.

To investigate the epidemiological characteristics and pathogen distribution of burn patients at the hospital.

The medical records of 2 434 burn patients who met the inclusion criteria in the First Affiliated Hospital of Anhui Medical University from 2019 to 2022 were analyzed, including sex, age, injury factors, burn site, burn severity, and seasonal distribution of burns, as well as the type of pathogen of infection, the source of tissue/body fluid and its drug resistance. The species of pathogens were identified by Matter-assisted Laser Desorption Time-of-flight Mass Spectrometry (VITEK-MS), and the drug sensitivity of the top three pathogens was determined by VITEK2 Compact. SPSS27.0 and WHONET5.6 statistical software were used to analyze the data.

A total of 2 434 burn patients were enrolled in this study, with a male-to-female ratio of 2.2915. The average age was 29.8 ±25.95 years old. Adults and the elderly were most likely to have burns in summer, while children were more likely to suffer from burns in spring. Hot water scald was the main cause of disease. A total of 952 strains of pathogenic bacteria were collected, all of which were isolated for the first time. The top five pathogens were Pseudomonas aeruginosa, Acinetobacter baumannii, Staphylococcus aureus, Klebsiella pneumoniae, and Enterobacter cloacae. The number of pathogens isolated from wound secretions was the largest, accounting for 83.93% (799/952). The resistance rate of Pseudomonas aeruginosa to the first and second generation cephalosporins was 100%, but the resistance rate to aztreonam, tobramycin,and piperacillin decreased. The resistance rates of Acinetobacter baumannii to polymyxin B, minocycline, and tigecyclines were all 0, and the resistance rates to other antibiotics were all ≥ 50.0%. The resistance rate to penicillin and Staphylococcus aureus was more than 90%, but it was completely sensitive to vancomycin, linezolid, tigecyclines, and ampicillin/sulbactam.

Based on the age range division, there are significant differences in gender, cause of injury, prehospital treatment, burn severity, and burn site. Scald is the main cause of injury, limbs are the most prone to burn, and cases occur in summer most commonly. The main pathogen of burn infection is Pseudomonas aeruginosa, which mainly comes from wound secretions.