To investigate the heterogeneous development trajectories of early depression symptoms in adolescents and their influencing factors.

A cluster sampling method was employed to conduct four follow-up surveys from March 2023 to September 2024, targeting 1 118 seventh-grade students from junior high schools in the Hunan-Hubei-Chongqing-Guizhou border area. Each survey was spaced six months apart, utilizing the Depression Symptoms Scale, Family Support Scale,Peer Relationship Scale, and School Connection Scale. Group-based Trajectory Modeling (GBTM) was used to explore the heterogeneous development trajectories of early depression symptoms in adolescents, while multi-class logistic stepwise regression analysis was performed to identify the relevant factors associated with different latent developmental trajectories.

Four subtypes were identified: “G1: Low Risk-Deterioration Group” (8.27%), “G2: High Risk-Persistent Group”(3.73%), “G3: Low Risk-Stable Group” (78.24%), and “G4: High Risk-Relief Group” (9.76%). Using the G3 group as a reference, the protective factors for the G1 group included being male (OR=0.417, 95%CI: 0.297-0.585), family support (OR=0.870, 95%CI: 0.641-0.923), peer relationships (OR=0.829, 95%CI: 0.740-0.998), and school connection (OR=0.865, 95%CI:0.725-0.906); risk factors included boarding (OR=1.310, 95%CI: 1.154-2.010), being left-behind (OR=2.196, 95%CI: 1.376-3.503), single-parent families (OR=2.247, 95%CI: 1.456-3.468), and low Family Economic Status (FSES) (OR=1.548, 95%CI:1.371-2.451). For the G2 group, protective factors included being male (OR=0.318, 95%CI: 0.263-0.521), family support (OR=0.856, 95%CI: 0.817-0.991), and peer relationships (OR=0.849, 95%CI: 0.711-0.988); risk factors were boarding (OR=1.332,95%CI: 1.022-2.058), being left-behind (OR=1.422, 95%CI: 1.211-3.218), single-parent families (OR=2.953, 95%CI: 1.659-4.256), and low FSES (OR=2.469, 95%CI: 1.188-3.128). For the G4 group, being male (OR=1.350, 95%CI: 1.001-1.513) was identified as a risk factor, while family support (OR=0.892, 95%CI: 0.751-0.943) and school connection (OR=0.846, 95%CI:0.705-0.961) were protective factors.

There is significant group heterogeneity and individual variability in early depression symptoms among adolescents. It is crucial to focus on the “Low Risk-Deterioration Group” and “High Risk-Persistent Group” to enhance the breadth and depth of their interpersonal support networks.

To explore the reciprocal predictive relationship between adolescent peer relationships and depression and anxiety, providing a basis for the implementation of mental health education for adolescents.

A longitudinal survey was conducted using the Center for Epidemiologic Studies Depression Scale (CES-D) and the Screen for Child Anxiety Related Emotional Disorders (SCARED) among 3 840 students in grades 1-8 in Chengdu, Sichuan Province, over four waves spanning three years. The Random Intercept Cross-Lagged Panel Model (RI-CLPM) was employed to investigate the bidirectional relationships between peer relationships and depression and anxiety.

Among the participants, there were 1 877 boys, accounting for 48.9%. The age distribution was as follows: 1 100 individuals aged 6 to 8 years (28.7%), 1 768 individuals aged 9 to 11 years (46.1%), and 965 individuals aged 12 to 16 years (25.2%). In terms of grade distribution, there were 1 400 students in grades 1 to 3 (36.5%), 1 702 students in grades 4 to 6 (44.3%), and 738 students in grades 7 to 8 (19.2%). The results of the cross-lagged model indicated a significant negative correlation between peer relationships and depression and anxiety at the individual level (β=-0.71, P<0.001; β=-0.45, P<0.001). At the individual level, peer relationships at the previous time point significantly negatively predicted depression and anxiety at the subsequent time point, except for the fourth wave. Additionally, depression and anxiety at the previous time point significantly negatively predicted peer relationships at all follow-up time points.

This study reveals a complex bidirectional predictive relationship between adolescent peer relationships and depression and anxiety, offering theoretical insights and practical significance for adolescent mental health care and preventive interventions.

To investigate the relationship between hemoglobin (Hb) levels in early pregnancy and the incidence of gestational diabetes mellitus (GDM).

Following the principle of informed consent, data were collected from pregnant women who underwent prenatal care and delivery at ten hospitals and fifteen community health service centers in Kunshan,Jiangsu Province, from August 2019 to June 2021. This included demographic information, medical and family history, reproductive history, physical examinations, and laboratory test results. GDM was diagnosed based on the results of the oral glucose tolerance test during pregnancy. A restricted cubic spline (RCS) regression analysis was employed to explore the dose-response relationship between Hb levels and the risk of GDM. Based on the RCS results, Hb levels were categorized into two groups: Hb ≤ 138.4 g/L and Hb > 138.4 g/L. Logistic regression was then used to analyze the relationship between early pregnancy Hb levels and the risk of GDM, calculating the odds ratio (OR) and its 95% confidence interval (95%CI) to assess the strength of the association.

Totally 9 045 women with singleton pregnancy were included in this study, with an incidence of GDM of 14.72% (n=1 331). The RCS regression results indicated a linear relationship between early pregnancy Hb levels and the risk of GDM (overall trend test: P=0.013, non-linear test: P=0.396). Multivariable logistic regression revealed that women with Hb > 138.4 g/L had a higher risk of GDM compared to those with Hb ≤ 138.4 g/L, with an adjusted OR of 1.214 (95%CI: 1.021-1.445).

Elevated Hb level in early pregnancy is a risk factor for the development of GDM.

To analyze the distribution characteristics of mothers with different parities in Hebei Province and their impact on pregnancy outcomes.

Data from 398 111 mothers who delivered in 22 hospitals across 10 cities in Hebei Province were analyzed. Based on previous delivery counts (excluding the current hospitalization), mothers were categorized into three groups:primipara (parity=0), multipara (parity=1), and grand multipara (parity≥2). The distribution characteristics of mothers by parity were analyzed, and the influence of different parities on pregnancy outcomes was assessed using multifactorial logistic regression.

From 2014 to 2022, the average age of mothers in all three groups showed an upward trend, as did the proportion of grand multipara mothers. With the increase in hospital level, the proportion of primipara mothers rose, while the proportions of multipara and grand multipara mothers declined. The proportion of primipara mothers in provincial and municipal hospitals was higher than that in county and township hospitals, where the proportions of multipara and grand multipara mothers were lower. As parity increased, the incidence rates of anemia, placenta previa, placental abruption, preterm birth, cesarean delivery, macrosomia, low Apgar scores, and perinatal mortality also increased. Conversely, the incidence rates of gestational diabetes, gestational hypertension, abnormal fetal position, soft birth canal lacerations, postpartum hemorrhage, and low birth weight exhibited a “U” trend. Using primipara (parity=0) mothers as the reference group, the results of the multifactorial logistic regression analysis indicated that parity≥1 was a risk factor for anemia (OR=1.041, 95%CI: 1.024-1.058), gestational diabetes (OR=1.301, 95% CI: 1.237-1.375), placenta previa (OR=1.565, 95% CI: 1.359-1.802), soft birth canal lacerations (OR=1.394, 95% CI: 1.157-1.681), and macrosomia (OR=1.222, 95%CI: 1.189-1.257). In contrast, it was a protective factor against gestational hypertension (OR=0.677, 95% CI: 0.651-0.703),abnormal fetal position (OR=0.650, 95% CI: 0.617-0.684), cesarean delivery (OR=0.296, 95% CI: 0.290-0.301), and low birth weight (OR=0.872, 95% CI: 0.830-0.917). Parity≥2 was identified as a risk factor for preterm birth (OR=1.470, 95% CI: 1.372-1.575) and postpartum hemorrhage (OR=1.242, 95% CI: 1.086-1.420).

The risk of adverse pregnancy outcomes varies with parity. Targeted prevention of gestational complications and comorbidities should be implemented during prenatal care for mothers of different parities to reduce the risk of adverse maternal and infant outcomes.

To analyze the factors influencing overweight and obesity among middle school students and to establish a nomogram for predicting the risk of overweight and obesity in this population.

From September to November 2024, a random cluster sampling method was used to select 5 135 middle school students from 20 schools in Tongren city for physical examinations and questionnaire surveys. Lasso regression was employed to identify factors affecting overweight and obesity, and a nomogram prediction model was established and validated.

The prevalence of overweight and obesity among middle school students was 25.02%. Multivariate logistic regression analysis revealed that being female (OR=0.430, 95%CI: 0.371-0.499),boarding at school (OR=0.582, 95%CI: 0.500-0.678), engaging in moderate to high-intensity physical activity for one hour daily (OR=0.730, 95%CI: 0.630-0.847), having non-obese parents (OR=0.466, 95%CI: 0.404-0.538), and external eating triggers (OR=0.945, 95%CI: 0.935-0.956) were protective factors against overweight and obesity. Conversely, consuming fresh fruits and vegetables at every meal (OR=1.308, 95%CI: 1.103-1.549), restrictive eating (OR=1.100, 95%CI: 1.089-1.111), and emotional eating (OR=1.091, 95%CI: 1.079-1.103) were identified as risk factors. The areas under the curve (AUC) for the training and validation sets were 0.790 (95%CI: 0.775-0.806) and 0.765 (95%CI: 0.731-0.799), respectively, indicating good discrimination of the nomogram prediction model. The Brier score was 0.15, and the Hosmer-Leeshawn test suggested good model fit (χ²=10.984, P=0.203).

The nomogram model established in this study effectively predicts the risk of overweight and obesity, providing a reference for screening high-risk students and implementing personalized prevention strategies.

To investigate the factors influencing Guangzhou residents’ willingness to use “Internet + pharmaceutical services”, providing references for optimizing related service platforms.

A questionnaire was designed based on the UTAUT model, and from January to May 2024, residents of Guangzhou were surveyed. Structural equation modeling was utilized to test the path relationships and mediating effects, constructing a model of the influencing factors on residents’ willingness to use“Internet + pharmaceutical services”.

Social influence (β=0.319, P<0.001), effort expectancy (β=0.264, P<0.05), and performance expectancy (β=0.256, P<0.001) positively impacted the willingness of Guangzhou residents to use “Internet +pharmaceutical services”. Social influence had a significant positive effect on performance expectancy (β=0.764, P<0.001), and performance expectancy partially mediated the positive effect of social influence on willingness to use. Facilitating factors (P>0.05) did not have a significant effect on willingness.

Performance expectancy, effort expectancy, and social influence are the main factors affecting Guangzhou residents’willingness to use “Internet + pharmaceutical services”. Related platforms should innovate and improve their design based on residents’ needs, ensuring the practicality and usability of services to enhance user experience. Additionally, promoting and publicizing “Internet + pharmaceutical services” should be strengthened to leverage social influence, thereby increasing public recognition and willingness to use.

To understand the current status of health information avoidance behavior regarding AIDS prevention among rural middle-aged and elderly individuals aged 50 and above, and to analyze its influencing factors.

From September to December 2024, a convenience sampling method was employed to select 751 middle-aged and elderly individuals from rural areas in five districts of Luzhou city for the study. A general information questionnaire, AIDS prevention health information avoidance scale, brief health literacy scale, self-neglect scale, and AIDS discrimination scale were utilized for data collection. Statistical analyses including t-tests, ANOVA, Pearson correlation analysis, and multiple linear regression were conducted to analyze influencing factors.

The average score for health information avoidance behavior regarding AIDS prevention among rural middle-aged and elderly individuals was (31.64±10.08). The influencing factors included education level (β=-0.066, 95%CI: -0.122 to -0.010), age (β=0.074,95%CI: 0.021-0.127), being widowed (β=-0.089, 95%CI: -0.154 to -0.024), employment status (β=0.061, 95%CI: 0.004-0.118),health literacy (β=-0.267, 95% CI: -0.337 to -0.197), self-neglect (β=0.267, 95%CI: 0.199-0.334), and AIDS discrimination (β=0.344, 95%CI: 0.279-0.408) (all P<0.05), collectively explaining 64.10% of the total variance.

The health information avoidance behavior regarding AIDS prevention among the rural middle-aged and elderly population is at a moderately high level. To reduce this behavior, it is essential to focus on individuals with lower health literacy, higher levels of self-neglect, greater discrimination against AIDS, older age, lower educational attainment, and those engaged in labor. Targeted measures should be implemented to improve this population’s willingness and ability to access and apply AIDS prevention health information

To explore the potential pathways influencing self-management behaviors among community patients with peptic ulcers, providing a basis for interventions aimed at enhancing self-management in this population.

From March to August 2024, a stratified cluster sampling combined with convenience sampling was employed to randomly select 640 community patients with peptic ulcers from five administrative districts in Hengyang city for a questionnaire survey. Data analysis was conducted using SPSS 26.0 for t-tests, ANOVA, and partial correlation analysis, and a chain mediation model was constructed using Process 4.0 plugin model 6.

Health literacy had a significant direct effect on self-management (b=0.322, 95%CI: 0.254-0.390); the mediating effects of social support and self-efficacy between health literacy and self-management were 0.067 (95%CI: 0.043-0.098) and 0.100 (95%CI: 0.069-0.135), respectively. The chain mediating effect of social support and self-efficacy was also significant (b=0.016, 95%CI: 0.008-0.025).

Enhancing the level of health literacy among community patients with peptic ulcers is beneficial for improving social support and increasing self-efficacy, thereby enhancing self-management levels.

To analyze the composition, mortality, and corresponding trends of hospitalized patients with malignant tumors in Chengdu from 2016 to 2020, providing an effective reference for cancer prevention and control in Chengdu and its districts and counties.

Based on relevant information from the first hospitalization records of malignant tumor patients in 87 municipal and county-level hospitals in Chengdu from 2016 to 2020, this study analyzed the composition of hospitalized malignant tumor patients, the incidence by age group, mortality, and their trends across different regions of Chengdu.

From 2016 to 2020, the total number of first-time hospitalized malignant tumor patients in Chengdu’s 87 hospitals was 287 901 (165 359 males and 122 542 females). The top five malignant tumor cases were lung cancer, rectal cancer, liver cancer, esophageal cancer, and colon cancer. Over the five years, the total number of hospitalized malignant tumor patients in the city showed an increasing trend, rising from 46 377 cases in 2016 to 65 488 cases in 2020, with a fixed-base growth rate of 41.2%.In 2020, compared to 2016, the number of hospitalized malignant tumor patients decreased in Xinjin District, Shuangliu District, Pengzhou city, and Dayi County, with decrease rates of 44.7%, 10.3%, 6.0%, and 1.9%, respectively; while in other districts and counties, the number of hospitalized malignant tumor patients increased, with the fastest growth observed in Pidu District, Wuhou District, Jinjiang District, Wenjiang District, and Jintang County, with fixed-base growth rates of 143.0%,119.6%, 111.0%, 56.3%, and 53.4%, respectively. The number of deaths among hospitalized malignant tumor patients was 21 381 (13 808 males and 7 573 females), with the mortality from various malignant tumors increasing annually, from 3 742 cases in 2016 to 4 504 cases in 2020, resulting in a fixed-base growth rate of 20.4%. The top five malignant tumors by mortality were lung cancer, liver cancer, colon cancer, esophageal cancer, and gastric cancer.

The burden of malignant tumors in Chengdu is increasing, with slight variations in the composition and mortality of malignant tumors across different districts and counties, indicating the need for localized cancer prevention and control policies.

To understand the prevalence of health abnormalities detected in health examinations of elderly individuals aged ≥65 in Shenzhen from 2021 to 2023.

This study extracted health examination records of all participants aged ≥65 who underwent free health check-ups as part of the National Basic Public Health Service Project in Shenzhen from 2021 to 2023.The prevalence rates of single, dual, and triple health abnormalities were described, and the co-occurrence rates of two diseases were analyzed by gender and age groups.

A total of 1 194 927 health examination records were reviewed from 2021 to 2023, showing an overall increasing trend in the detection rate of health abnormalities among the elderly, which remained high.The detection rate for overweight or obesity ranked first, ranging from 59.0% to 59.5% during this period. The highest co-occurrence rate was observed for overweight or obesity combined with dyslipidemia or abnormal blood lipids, ranging from 34.3%to 35.3%. Overall, females and individuals aged 75 and older exhibited higher health risks. Furthermore, the highest cooccurrence of three health abnormalities was found in individuals with overweight or obesity, electrocardiogram abnormalities, and dyslipidemia or abnormal blood lipids, with a detection rate of 19.2% to 20.1%.

Among elderly individuals aged ≥65,the highest detection rate was for overweight or obesity, which frequently coexists with other chronic diseases. There is a pressing need to focus on women and older seniors. Public health institutions at the grassroots level should enhance health management for early detection, intervention, and treatment of key diseases and populations.