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Independent and joint effects of knee osteoarthritis and sarcopenia on fall risk among middle-aged and older adults in China
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De-zhi WANG, Wen-rong PU, Ming ZHU, Chao MA, Yu-long LIU, Hu MENG
Modern Preventive Medicine | 2025, 52(13) : 2484 - 2490
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Modern Preventive Medicine | 2025, 52(13): 2484-2490
• Clinical Medicine and Prevention •
Independent and joint effects of knee osteoarthritis and sarcopenia on fall risk among middle-aged and older adults in China
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De-zhi WANG, Wen-rong PU, Ming ZHU, Chao MA, Yu-long LIU, Hu MENG
Affiliations
  • Rizhao Hospital of Traditional Chinese Medicine, Rizhao, Shandong 276800, China
Published: 2025-07-10 doi: 10.20043/j.cnki.MPM.202412303
Outline
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Objective

To evaluate the independent and joint effects of knee osteoarthritis (KOA) and sarcopenia on fall risk among Chinese middle-aged and older adults.

Methods

Using data from the China Health and Retirement Longitudinal Study (CHARLS), we analyzed baseline data from 2011 and recorded fall events during 9-year follow-up. Multivariable Cox regression models were established to examine independent and joint effects, with sensitivity analyses conducted to verify robustness.

Results

Among 9 037 participants, 3 627 (40.1%) experienced falls during follow-up. Multivariable Cox regression showed both KOA (HR=1.51, 95%CI: 1.38-1.65) and sarcopenia (HR=1.25, 95%CI: 1.11-1.40) were independent risk factors for falls. For joint effects, compared with the non-KOA/non-sarcopenia group, the non-KOA/sarcopenia (HR=1.25, 95%CI:1.09-1.42), KOA/non-sarcopenia (HR=1.51, 95%CI: 1.37-1.67), and KOA/sarcopenia (HR=1.83, 95%CI: 1.46-2.29) groups all showed increased fall risks. Sensitivity analyses confirmed result stability.

Conclusion

Both KOA and sarcopenia increase fall risk in middle-aged and older adults, with their combined effect exceeding individual impacts. Enhanced fall prevention strategies combining early intervention and comprehensive measures should be implemented for this vulnerable population.

Middle-aged and older adults  /  Knee osteoarthritis  /  Sarcopenia  /  Fall risk  /  China Health and Retirement Longitudinal Study
De-zhi WANG, Wen-rong PU, Ming ZHU, Chao MA, Yu-long LIU, Hu MENG. Independent and joint effects of knee osteoarthritis and sarcopenia on fall risk among middle-aged and older adults in China[J]. Modern Preventive Medicine, 2025 , 52 (13) : 2484 -2490 . DOI: 10.20043/j.cnki.MPM.202412303
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Year 2025 volume 52 Issue 13
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Article Info
doi: 10.20043/j.cnki.MPM.202412303
  • Receive Date：2024-12-18
  • Online Date：2026-03-19
  • Published：2025-07-10
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  • Received：2024-12-18
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    Rizhao Hospital of Traditional Chinese Medicine, Rizhao, Shandong 276800, China
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表12种不同金属材料的力学参数
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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