Objective To compare the role of enzyme-linkedimmunosorbent assay and toluidine red unheated serum test in thediagnosis of syphilis. Methods 78 suspected syphilis patients in ourhospital were analyzed from January 1st, 2023 to December 31st, 2023,enzyme linked immunosorbent assay and toluidine red unheated serum testwere performed on all patients, and the testing procedures were strictlyfollowed according to the instructions. Compare the diagnosticsensitivity, specificity, and accuracy of enzyme-linked immunosorbentassay (ELISA) and toluidine red unheated serum test based on the resultsof syphilis Treponema pallidum gelatin particle agglutination test.Results The sensitivity, specificity, and accuracy of the enzyme-linkedimmunosorbent assay were 93.24%, 75%, and 92.31%, respectively. Thesensitivity, specificity, and accuracy of the toluene red unheated serumtest were 82.43%, 50%, and 80.77%, respectively. The toluene redunheated serum test was lower than the enzyme-linked immunosorbentassay, with a difference of $P<{0.05}$ . Conclusion Enzyme linked immunosorbent assay(ELISA) has higher sensitivity and accuracy in syphilis testing comparedto the non heated serum test with toluidine red, and is worthy ofattention and promotion.

Objective Exploring the effect of nicotinamide concentration on skin melanin transfer and its mechanism of action, to provide a scientific basis for the development and application of related skin care products and beauty technology. Methods The mechanism of nicotinamide inhibiting the formation of melanin was elucidated, and the main influencing factors of the formation of black spots were analyzed, so as to control the formation and transfer of melanin. The researchers then combined a variety of substances, including arbutin, phenylresorcinol, and vitamin C and its derivatives, to study. Results Nicotinamide was able to effectively inhibit the diffusion rate of melanin by blocking the transfer process of melanin particles to epidermal cells. When used in combination with arbutin, phenylethyresorcinol and vitamin C, its inhibitory effect is more obvious. Conclusion Niacinamide and its synergistic effect with other substances can effectively inhibit the transfer and diffusion of melanin, providing a new way for skin whitening. This discovery provides an important reference for the application and development of related skin care products and beauty technologies.

The purpose of this paper is to discuss the application of Liquid Chromatography-Mass Spectrometry (LC-MS) in drug quality analysis in order to improve the accuracy and efficiency of drug detection. The basic principle, equipment and application of LC-MS in drug quality analysis are reviewed in this paper. LC-MS technology has shown excellent performance in the qualitative, quantitative, fingerprint and pharmacokinetics of drugs, providing an efficient and accurate tool for drug quality analysis, and has a broad application prospect.

The article delves into real-time data processing methods for monitoring tool wear in computer numerical control (CNC) machine tools, with the aim of improving the overall accuracy of the tool monitoring system. The article also systematically reviews several mainstream data processing methods, including power spectrum analysis, wavelet transform, artificial neural network technology, and multi-sensor information fusion technology. Although these methods have their own advantages and disadvantages, a single method often fails to achieve ideal results when dealing with data in complex and changing processing environments. To overcome this challenge, this paper proposes a multi-sensor information fusion data processing method based on hybrid intelligent algorithms

Objective By analyzing the original detection results of urine organic acids in Changchun, Jilin Province, this study aims to explore the incidence of genetic metabolic diseases related to urine organic acid detection projects in Changchun, Jilin Province, and analyze the detection data. Methods Gas chromatography-mass spectrometry (GC-MS) was used to analyze the results of the urine organic acid detection project submitted by Jilin Jincheng Medical Co., Ltd. in Changchun, Jilin Province from January 2019 to May 2023. Results there were 83 cases of positive diseases in the initial screening, with a positive rate of 3.93%. Among them, there were 43 cases of methylmalonic acidemia with a positive rate of 51.81%, 10 cases of hyperphenylalaninemia with a positive rate of 12.05%, 6 cases of glutaric acidemia type 1 with a positive rate of 7.23%, 5 cases of Citrin protein deficiency with a positive rate of 6.02%, 5 cases of propionaemia with a positive rate of 6.02%, 4 cases of maple diabetes with a positive rate of 4.82%, and 10 cases of other diseases with a positive rate of 12.05%. Conclusion Organic acid metabolism disease, also known as organic aciduria, is the most common genetic metabolic disease. Urine organic acid screening is an effective method for preventing and treating certain genetic metabolic diseases after birth, among which methylmalonic acidemia is the most common genetic metabolic disease with abnormal organic acid metabolism. In order to improve the survival rate and quality of life of children, people must raise awareness, detect, diagnose and treat them early.

Smart laboratories play an important role in scientific research and production, however, they also face safety risks and management challenges. Building a smart laboratory safety management platform system can help laboratory managers comprehensively manage laboratory safety risks. In order to effectively manage the safety issues of smart laboratories, this study aims to build a comprehensive smart laboratory safety management platform system. By formulating the use of inspection equipment, the management of hazardous chemicals in the laboratory, the laboratory environment monitoring, and ensuring capital investment, a laboratory safety funding guarantee system is built. Through innovative applications of Internet of Things technology and other measures, the functions of the smart laboratory safety management platform system are realized, so that the safety and management efficiency of the laboratory are improved.

Laboratory is an important structure in the field of health inspection, and the management level of laboratory directly affects the effect of disease control and prevention. In recent years, with the vigorous development of the laboratory field, the emergence of many new laboratory reagents and laboratory technologies has effectively improved the efficiency of clinical laboratory, but it also poses new challenges to the development of existing laboratory management. The lack of reagent management system, the lack of talent team construction and the inability of information technology advantages are one of the practical difficulties of laboratory management at this stage. It is difficult to avoid the influence of human factors on the quality of inspection, and it is impossible to promote the high-quality development of inspection work. In recent years, with the development of emerging technology industry, emerging technology has potential value in the optimization management of laboratory. This paper reviews four emerging technologies, namely automation pipeline, artificial intelligence technology, cloud management platform and virtual simulation, aiming to solve the problem of lack of reagent management system in traditional laboratory inspection management and difficulty in highlighting the advantages of information technology. So as to promote the inspection laboratory management system update iteration, towards the direction of digital, scientific development.

Against the backdrop of increasingly collaborative global scientific research, regional joint laboratories have gradually gained attention as important platforms for improving research efficiency and transforming achievements. As an effective platform for integrating regional research resources and promoting deep integration of industry, academia, and research, research consortia can play a key role in enhancing regional innovation capabilities of regional joint laboratories and accelerating the transformation of scientific and technological achievements. This article aims to explore the construction and open sharing strategy of regional joint laboratories based on research consortia, analyze the challenges and opportunities faced in the current construction and operation of regional joint laboratories, and propose corresponding countermeasures and suggestions.

Aspirin is a commonly used drug in clinical practice, which is well-known to the public for its precise therapeutic effect and minimal adverse drug reactions. Based on the research results of aspirin content determination methods in recent years, this paper introduces the research progress of titration, ultraviolet and visible spectrophotometry, high performance liquid chromatography, near infrared diffuse reflectance method, etc. in determining aspirin content, providing a reference basis for further developing new detection methods for aspirin.

Objective To observe the test results and substantial impact of real-time fluorescence quantitative PCR detection technology in detecting hepatitis B virus DNA. Methods 1500 patients with hepatitis B from January 2023 to December 2023 were selected for the study data, and all of them were detected by serological markers and real-time fluorescent quantitative PCR. The control standard was the clinical diagnosis results, and the comparison index was the DNA quantitative detection results. Results Among the 1500 confirmed hepatitis B patients, real-time fluorescence quantitative PCR technology detected hepatitis B virus DNA quantification results, which showed that the viral load of 1380 patients (92.00%) could be clearly quantified, while the serological marker method could only clearly quantify the viral load of 1260 patients (84.00%). In addition to technology, factors that may affect the final test results include laboratory operations, sample and nucleic acid extraction, and storage at multiple stages. Conclusion Real time fluorescence quantitative PCR technology has higher sensitivity and accuracy compared to traditional serum blood marker detection methods, and is more suitable for modern laboratory medicine.