Objective Exploring the effect of nicotinamide concentration on skin melanin transfer and its mechanism of action, to provide a scientific basis for the development and application of related skin care products and beauty technology. Methods The mechanism of nicotinamide inhibiting the formation of melanin was elucidated, and the main influencing factors of the formation of black spots were analyzed, so as to control the formation and transfer of melanin. The researchers then combined a variety of substances, including arbutin, phenylresorcinol, and vitamin C and its derivatives, to study. Results Nicotinamide was able to effectively inhibit the diffusion rate of melanin by blocking the transfer process of melanin particles to epidermal cells. When used in combination with arbutin, phenylethyresorcinol and vitamin C, its inhibitory effect is more obvious. Conclusion Niacinamide and its synergistic effect with other substances can effectively inhibit the transfer and diffusion of melanin, providing a new way for skin whitening. This discovery provides an important reference for the application and development of related skin care products and beauty technologies.

nicotinamide concentration  /  skin melanin  /  impact mechanism