In order to promote the green, low-carbon and high-quality development of rural areas in western Inner Mongolia, the data collected from the survey and literature was combined, the energy consumption of farmhouses was jointly simulated through DeST and Trnsys software, single factor analysis was carried out, the orthogonal test method was used to obtain multiple schemes, and the gray fuzzy comprehensive evaluation method based on random forest algorithm was used to comprehensively optimize the enclosure structure and heating system, and selected the most suitable green and low-carbon farmhouse scheme in western Inner Mongolia. The results show that the optimal scheme of green and low-carbon farmhouses in western Inner Mongolia is as follows: the building is facing north and south, the floor height is${3.4}\mathrm{\;m}$, the ground is${20}\mathrm{\;{mm}}$polystyrene extruded polystyrene board (XPS) thermal insulation tile floor, the roof is${120}\mathrm{\;{mm}}$expanded polystyrene foam board (EPS) insulation board inverted concrete block roof, the external wall is${160}\mathrm{\;{mm}}$polystyrene extruded polystyrene board (XPS) insulation board external insulation concrete block wall, the external window is$6\mathrm{C}+ {12}\mathrm{{Ar}}+ 6\mathrm{C}6\mathrm{\;{mm}}$double-layer ordinary glass inert gas plastic steel window, the south-facing window-to-wall ratio is 0.5, the north-facing window-to-wall ratio is 0.5, and the sunlight depth is${1.2}\mathrm{\;m}$. The material of the sunshine room is$6\mathrm{C}+ {12}\mathrm{{Ar}}+ 6\mathrm{C}6\mathrm{\;{mm}}$double-layer inert gas ordinary glass + plastic steel window frame + thermal insulation curtains, and the wind power generation efficiency is${45}\%$. The heating energy consumption of the optimal scheme is${2661.15}\mathrm{\;{kW}}\cdot \mathrm{h}$,the average indoor temperature on the coldest day is${11.62}{}^{\circ }\mathrm{C}$, the carbon emission reduction is${10.02}\mathrm{\;t}/\mathrm{a}$, the solar heat gain is${67702.75}\mathrm{\;{kW}}$, and the net present value$> 0$, which is economical and has a certain degree of popularization in the rural areas of western Inner Mongolia, providing a development direction for the green and low-carbon transformation of rural houses in western Inner Mongolia.

The pathogenesis of diabetic nephropathy is complex and can ultimately progress to end-stage renal disease, imposing a heavy burden on patients. Current treatment methods show limited efficacy. The protein kinase RNA-like endoplasmic reticulum kinase (PERK)-eukaryotic initiation factor-2$\alpha$(elF2$\alpha$) -activating transcription factor 4 (ATF4)-C/EBP homologous protein (CHOP) signaling pathway serves as a critical pathway in endoplasmic reticulum stress, with downstream regulation of pathological processes such as apoptosis and autophagy closely related to the progression of diabetic nephropathy. Traditional Chinese medicine regulates the PERK-eIF2$\alpha$-ATF4-CHOP pathway through methods that tonify$\mathrm{{Qi}}$and nourish$\mathrm{{Yi}}$, strengthen the spleen and benefit the kidneys, promote diuresis and reduce edema, clear heat and detoxify, as well as invigorate blood and eliminate stasis. These interventions protect the glomerular filtration barrier, reduce capillary basement membrane thickening, enhance protein reabsorption in urine, and delay renal interstitial fibrosis. The mechanistic role of the PERK-eIF2$\alpha$-ATF4-CHOP signaling pathway in diabetic nephropathy was elucidated, the theoretical basis for traditional Chinese medicine interventions in this pathway was summarized, and recent advances were reviewed in the mechanisms of action of effective components of traditional Chinese medicine targeting this pathway, aiming to provide new ideas and methods for the prevention and treatment of diabetic nephropathy through traditional Chinese medicine.

In order to study the formation mechanism, paleoenvironment, paleoclimate, tectonic background, and source of black shale in the Shengping Formation of the Middle Ordovician in northern Guangxi, sixteen samples of black shale and black siliceous shale were collected from the Shengping Formation at Xishuiyuan section in Quanzhou County, Guilin City, Guangxi Zhuang Autonomous Region, and element geochemistry testing and analysis were conducted on them. The results show that the content of the main element${\mathrm{{SiO}}}_{2}$in the black shale of the Shengping Formation at Xishuiyuan section is the highest (${62.37}\%\sim {91.65}\%$, average${78.04}\%$), followed by${\mathrm{{Al}}}_{2}{\mathrm{O}}_{3}({2.88}\%\sim$16.92%, average 9.15%). Compared with the North American shale (NASC), the content of trace elements in the study area shows a loss for all elements. The value of the sample${\left(\mathrm{{La}}/\mathrm{{Yb}}\right)}_{\mathrm{N}}$is${7.185}\sim {15.858}$, with an average of 10.678. The light rare earth elements (LREE)/ heavy rare earth elements (HREE) values are${8.165}\sim {15.440}$, with an average of 11.029. It indicates that the differentiation phenomenon of light and heavy rare earth elements is more obvious, and LREE are relatively enriched compared to HREE. The δEu value exhibits negative anomalies$\left({{0.589}\sim {0.950}}\right)$, with an average value of 0.758 ; The$\delta \mathrm{{Ce}}$value exhibits positive anomalies$\left({{1.165}\sim {1.412}}\right.$, with an average of 1.259). The geochemical characteristics show that the structural background of the black shale source area in the Shengping Formation of the Xishuiyuan profile is passive continental margin, and the source rock type is sedimentary rock. The source area has undergone moderate to strong chemical weathering, which is greatly affected by chemical weathering, with a predominantly warm and humid climate. The sedimentary environment is mainly a deoxidizing environment with oxygen deficiency.

The accurate detection of coke overflow in high-dust environments is a pivotal challenge in achieving intelligent coke loading. A method was proposed to address this issue for the intelligent detection of coke loading overflow, which was based on dark channel prior knowledge and the ResNet network. Firstly, a video collector was used to obtain video information of the coke loading scene, and the original time-series video image frames were processed to obtain the region of interest between the discharge port and the loader. Secondly, the prior knowledge method of dark channels was employed to process the regions of interest. Enhancing the contrast between the target areas and irrelevant areas within the regions of interest, thereby mitigating the effects of dust on subsequent detection models. Moreover, the problem of overflow detection was transformed into a binary classification task by labeling the regions of interest based on the actual loading of coke. Finally, the ResNet network was utilized for modeling, enabling the completion of model training and experimentation during the loading process of newly acquired coke. The experimental results demonstrate that the proposed method exhibits promising performance on new data, achieving an overall accuracy of 86.81%. Specifically, the accuracy, recall, and F1 score for the overflow class are 84. 12%, 90.74%, and 0.8730, respectively. Furthermore, the application of the dark channel prior algorithm in data processing results in a notable increase in the recall rate of the overflow class by 3.31%.

In order to explore the efficient heat transfer characteristics of medium-deep coaxial buried pipe heat exchangers, a heat transfer model was constructed between the medium-deep coaxial buried pipe heat exchanger and surrounding rock and soil based on the fluid flow heat transfer equation. COMSOL software was used for numerical analysis and calculation of heat transfer, and the nominal heat transfer of the model was studied under different burial depths, inner pipe thermal conductivity, circulating water flow rate, and cementing material thermal conductivity conditions. The research results indicate that the thermal conductivity of the inner pipe, the flow rate of circulating water, and the thermal conductivity of the cementing material have a significant impact on the nominal heat extraction. The thermal conductivity of the inner tube decreases from${0.5}\mathrm{\;W}/\left({\mathrm{m}\cdot \mathrm{K}}\right)$to${0.002}\mathrm{\;W}/\left({\mathrm{m}\cdot \mathrm{K}}\right)$, with a nominal increase in nominal heat extraction of${289.4}\%$. The circulating water flow rate from${20}{\mathrm{\;m}}^{2}/\mathrm{h}$rises to${45}{\mathrm{\;m}}^{2}/\mathrm{h}$, with a nominal increase in nominal heat extraction of${124}\%$. The thermal conductivity of cementing materials increases from${0.8}\mathrm{\;W}/\left({\mathrm{m}\cdot \mathrm{K}}\right)$to${1.8}\mathrm{\;W}/\left({\mathrm{m}\cdot \mathrm{K}}\right)$, with a nominal increase in heat extraction of$2\%$. Finally, relying on a Pilot Demonstration Project of Medium and Deep Geothermal Energy for Building Heating at CCTEG Xi’an Research Institute (Group) Co., Ltd., differential analysis was conducted on experimental and simulation data under continuous operation for${168}\mathrm{\;h}$of the project. The research results have certain guiding significance for the optimization design of medium-deep coaxial buried pipe heat exchangers and the efficient development and utilization of medium-deep geothermal wells.

Seismic soil liquefaction can lead to soil instability and slip, resulting in irreversible and severe damage to bridges. The seismic response of curved bridges in liquefied lateral extension sites is a major concern due to the complex stress state. Three representative far-field seismic waves were selected and applied to a four-span continuous curved bridge from 12 different directions. The maximum tilt angle of the site was set to be the same as the seismic input angle in order to investigate the seismic response behavior of the curved bridge in the liquefaction expansion site and conduct a comparative analysis. The results show that as the far site seismic input gradually changes from${0}^{\circ }$to${180}^{\circ }$, the pile top bending moment of the curved bridge decreases gradually, with the side piers experiencing larger bending moments compared to the secondary center piers and the center piers. When the seismic input wave changes gradually from${180}^{\circ }$to${360}^{\circ }$, the pile top bending moment gradually increases, with the middle pier and the second pier experiencing higher bending moments than the side piers. The maximum bending moment at the bottom of the pier alternates between the middle pier and the second pier as the seismic input angle changes, with the second pier experiencing a significantly higher number of occurrences of the largest bending moment compared to the middle pier. The relative displacement between the pier and beam and the ground shaking input angle exhibits a cyclic trend of initially increasing and then decreasing. Therefore, it is recommended that the location of a bridge project susceptible to ground vibration should be determined based on the type of ground vibration, and corresponding anti-liquefaction measures should be implemented accordingly.

Based on the Wnt/β-catenin pathway, to investigate the anti-tumor effect of Gegen Qinlian Decoction (GQD) on colorectal cancer and its effect on nuclear translocation of protein regulator of cytokinesis 1 (PRC1). BALB/c nude mice were subcutaneously inoculated with the CT26 colorectal cancer cell line and divided into GQD low (L-GQD), medium (M-GQD), and high (H-GQD) dose groups, with the model group serving as the control. The mice were administered the drug daily for 25 days, and the growth of the tumors was recorded. Following the conclusion of the previous administration, the tumor was surgically excised and subjected to subsequent observation. The proliferation and apoptosis of the tumor were assessed using hematoxylin-eosin staining(HE), immuohistochemistry (IHC), and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining techniques, while the Wnt/B-catenin pathway was examined through qRT-PCR and western blot (WB) analysis. Furthermore, alterations in the expression of catenin signals and downstream factors were investigated. In addition, WB was used to detect the effects of GQD on the phosphorylation level of PRC1 and its subcellular localization. Compared with the model group, GQD inhibited the growth and increased the apoptosis level of colorectal tumors in vivo in a dose-dependent manner. IHC results show that GQD down-regulated the expressions of proliferation-related proteins cyclind1 , marker of proliferation Ki-67 (Ki67), and platelet endothelial cell adhesion molecule-1 (CD31)$\left({P <{0.05}}\right)$, and promoted the expressions of approbation-related proteins Caspase 3 and Caspase 9$\left({P <{0.05}}\right)$. GQD is further found to inhibit the activation of Wnt/β-catenin signaling, which may be related to the reduction of PRC1 phosphorylation level and the alteration of its nuclear retention ratio. This inhibition of Wnt/β-catenin signaling by GQD is closely associated with the suppression of colorectal tumor proliferation and the promotion of apoptosis. Moreover, GQD may involve in mediating nuclear translocation of PRC1.

In order to solve the problems of roof breakage, support difficulty, water and mud inrush encountered in underground space operations such as mining and tunnel excavation, polyester ammonia/water glass organic-inorganic hybrid grouting reinforcement material was taken as the research object. By establishing a similar simulation grouting model, the temperature and pressure of measuring points at different distances from the injection point during the model grouting process were studied, and the slurry diffusion law was analyzed. The mechanical properties of grouting reinforcement were analyzed to test the consolidation effect. The results show that the polyurethane(PU)/water glass double-liquid grouting material exhibits irregular diffusion in the broken rock test model, and the curing reaction is an exothermic reaction. It reaches a maximum of${83.2}\mathrm{C}$at 10 min after slurry injection, which is 6.6 times of room temperature. The maximum pressure is${5.7}\mathrm{{MPa}}$, which is 1.425 times of the test load. The temperature and pressure increase rapidly with time and then slowly decline and finally stabilize. The uniaxial compressive strength range of polyurethane/water glass double liquid grouting and solid is${15.32}\sim {32.57}\mathrm{{MPa}}$, the maximum bearing capacity of triaxial loading is${41.9}\mathrm{{MPa}}$, the residual strength is${25}\mathrm{{MPa}}$, the maximum load of creep failure is${25}\mathrm{{MPa}}$, and the strength of the injected material is greatly improved after consolidation. Through the microscopic analysis of grouting reinforcement, it can be seen that the rock and slurry are closely cemented at the junction, and the grouting reinforcement effect is good.

Charging infrastructure is essential for promoting the development of electric vehicles, and identifying charging behaviors of electric vehicles is the precondition of optimizing the layout of charging infrastructure. Using the charging data of the Kechuang Base Charging Station in Beijing in 2017, charging behaviors of electric vehicles were explored by descriptive analysis and statistical analysis. Based on the charging power, charging piles were divided into three categories: high(100kW), medium(40kW), and low (${10}\mathrm{\;{kW}}$and${15}\mathrm{\;{kW}}$). Firstly, a descriptive analysis was conducted. It is found that as the charging power decreases, the charging time significantly increases, but usually does not exceed 180 min. 86.5% of customers are company users, mainly consisted of taxi/ ride hailing drivers; electric vehicles are often charged when their state of charge (SOC) are still high. Then, an ordered Logistic model was built to identify the key factors influencing the charging pile choice. Company users, daytime, weekday, charging peak period, and the low starting SOC are found to be able to significantly lead users to adopt the high-power charging piles. The research findings could be used to help optimizing the charging station layout.

Based on the field pull destructive test of 9 anti-floating anchor of screw-thread steel bars in a foundation pit anti-float project in Qingdao, the load-displacement characteristics of anti-floating anchor of screw-thread steel bars under different anchoring lengths were studied, and the bearing performance of anti-floating anchor of screw-thread steel bars was determined. The results show that the ultimate uplift bearing capacity of the anti-floating anchor of screw-thread steel bars with the same diameter is 681 kN for the 3.0 m and 3.5 m anchors anchored in medium-weathered granite, and 1 004 kN for the 4.0 m anchors anchored in medium-weathered granite. At the initial stage of loading, the displacement of anchor head increase linearly, and with the increase of load, the displacement of anchor head increase abruptly, all of which exceed 50 mm. The agreement between the hyperbolic function and the power function load-displacement curve model and the measured value is good when the load level is low, but is relatively poor when the failure is near, and the predicted ultimate tensile strength is much different from the measured value. The exponential function load-displacement curve model can predict the ultimate uplift bearing capacity of the test anchors with high accuracy and good agreement with the measured curve.