Full
Outline
To develop and validate a nomogram prediction model for assessing drug resistance risk in patients with pulmonary tuberculosis and diabetes mellitus comorbidity (PTB-DM), identify associated risk factors, and provide a scientific basis for preventing and controlling drug resistance in this population.
A retrospective study was conducted on 546 PTB-DM patients hospitalized in the Department of Pulmonary Medicine at Shenzhen Third People’s Hospital between January 1, 2019, and December 31, 2024. Data collected included sex, age, marital status, smoking, alcohol use, hypertension, hepatitis B, admission type,pulmonary cavity formation, sputum smear results, drug resistance status, diabetes duration, glycated hemoglobin (HbA1c),hemoglobin (Hb), and albumin (ALB).
The indicators filtered by the lasso regression model were included in the multivariate logistic regression analysis, identifying age, admission type, diabetes duration, HbA1c, Hb, and ALB as six predictive factors. A predictive risk nomogram model was developed based on these risk factors. Internal validation using the bootstrap method demonstrated that the model exhibited good discrimination and calibration, with a corrected AUC of 0.781 (95% CI: 0.768-0.789). The calibration slope and intercept were 1.020 and -0.003, respectively, and the Hosmer-Lemeshow test indicated good model fit (χ2=4.06,P=0.852). The Brier score was 0.113 (95% CI: 0.111-0.116). This model may serve as a reference for clinical assessment of drug resistance risk in patients with PTB-DM.
The nomogram model, developed based on LASSO and Logistic regression analyses, demonstrated satisfactory performance in internal validation. It provides an initial predictive tool for assessing the risk of drug resistance in PTB-DM patients. However, its clinical applicability requires further validation with external data.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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