Full
Outline
To understand the detection situation and epidemiological characteristics of human bocavirus (HBoV) in influenza-like cases in Guizhou Province in 2024, and analyze the molecular typing characteristics of its VP1 gene.
10 823 throat swab samples of influenza-like cases in Guizhou Province in 2024 were collected.Usingthe multiplex fluorescence quantitative PCR method, common respiratory pathogens were analyzed, and the detection rates across different genders, ages, and seasons were described. Qualified HBoV-positive samples were screened for VP1 gene sequencing. Genotype using BLAST and MEGA 11, and constructing a phylogenetic tree using the adjacency method.
A total of 97 cases of HBoV were detected, with a detection rate of 0.90%. Among them, 44 cases were mixed infections, with a detection rate of 0.41% (44/10 823), and rhinovirus (HRV) was the main pathogen of mixed infections. There was no statistically significant difference in the detection rate of HBoV among different genders (χ2=2.732, P=0.098) and seasons (χ2=5.989, P=0.112). There was a statistically significant difference in the detection rate among different age groups (χ2=92.019, P<0.001), with the 0-4 age group having the highest detection rate, which was significantly different from the detection rates of the other three age groups. A total of 25 VP1 gene sequences of HBoV were obtained, all of which are HBoV1 type, including three evolutionary branches: 1b (17 strains), 1a (7 strains), and 1e (1 strain).
In the influenza-like cases in Guizhou Province in 2024, HBoV is at a low level of prevalence, all of which are HBoV1 type, with 1b as the main epidemic strain. The main infected population is 0-4 years old, and the monitoring of HBoV in young age groups should be continuously strengthened.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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