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Outline
To investigate association between Body Roundness Index (BRI) and all-cause and cardiovascular disease (CVD)-specific mortality among patients with CVD.
A total of 188 428 CVD patients from UK Biobank were included. Cox proportional hazards regression and restricted cubic spline (RCS) analyses were used to examine the association and dose-response relationship between BRI and risks of deaths. Subgroup and sensitivity analyses were also conducted.
Over a median follow-up of 12.75 years, 21 548 deaths occurred, including 5 367 CVD-related deaths. In multivariable Cox models, higher BRI was positively associated with risks of all-cause, CVD, and ischemic heart disease (IHD) mortality (P for trend <0.001). Compared with the lowest quintile (Q1), participants in the highest quintile (Q5) had 32% higher risk of all-cause mortality (HR=1.32, 95% CI: 1.26-1.38), 71% higher risk of CVD mortality (HR=1.71, 95% CI: 1.55-1.89), and 104% higher risk of IHD mortality (HR=2.04, 95% CI: 1.76-2.37); no significant association was observed for stroke mortality. RCS analyses indicated a J-shaped association of BRI with all-cause and CVD mortality. With BRI=4.45 as the threshold, relatively flat mortality risk below the threshold and a steep increase above it. BRI was positively associated with IHD mortality without clear evidence of nonlinearity, and showed no association with stroke mortality.
Among patients with CVD, BRI exhibits a J-shaped association with all-cause and CVD mortality, a positive association with IHD mortality, and no association with stroke mortality.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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