Full
Outline
To explore the interaction between shift work and hyperuricemia (HUA) on the prevalence of non-alcoholic fatty liver disease (NAFLD).
The demographic data, lifestyle, shift work conditions, liver ultrasound, serum uric acid and other data of 3 349 workers in an automobile manufacturing enterprise in Guangzhou were collected. The effects of shift work and HUA on the prevalence of NAFLD were analyzed by binary logistic regression. The influence of the interaction between shift work and HUA on the risk of NAFLD was analyzed through multiplicative and additive interactions.
Among 3 349 subjects, the detection rate of NAFLD was 41.36% (1 385/3 349), the detection rate of HUA was 52.05% (1 743/3 349), and the proportion of shift workers was 73.16% (2 450/3 349). The multivariate logistic regression analysis showed that shift work (OR=1.349, 95% CI: 1.087-1.676) and HUA (OR=1.732, 95% CI: 1.436-2.088) were the risk factors for NAFLD. Shift work and HUA had no multiplicative interaction on the prevalence of NAFLD (OR=0.910, 95% CI: 0.600-1.380). The additive interaction analysis of Model 2 (adjusted for age and BMI) and Model 3 (fully adjusted model) showed a synergistic effect between shift work and HUA. The relative excess risk due to interaction (RERI) , attributable proportion due to interaction (API) and synergy index (S) of Model 2 were 13.865 (95% CI: 4.320-23.411), 0.628 (95% CI: 0.507-0.749), and 2.922 (95% CI: 2.107-4.051), The RERI, API and S of Model 3 are respectively 14.025 (95% CI: 2.004-26.046), 0.625 (95% CI: 0.476-0.774), 2.891 (95% CI: 1.940-4.308).
Shift work and HUA have an additive interaction effect on the prevalence of NAFLD. Optimizing the shift scheduling system and controlling serum uric acid may coordinate the prevention of the occurrence of NAFLD.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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