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Outline
To investigate whether resveratrol has a protective effect against reproductive toxicity induced by nano titanium dioxide (Nano-TiO2) in male mice.
A total of 50 healthy male ICR mice were randomly divided into the control group, Nano-TiO2 group, and mixed groups with Nano-TiO2 plus low-, medium-, and high-dose resveratrol. After 28 days of continuous gavage, epididymal tissue was collected for semen quality measurement, and testicular tissue was used to evaluate pathological changes, testicular tissue-specific functional enzymes, and oxidative damage related indicators.
After exposure to Nano-TiO2, the testicular and epididymal coefficients of mice decreased significantly (P<0.05), sperm density and vitality decreased significantly (P<0.05), sperm deformity rate increased significantly (P<0.05), the number of spermatogenic cells in the testicular seminiferous tubules decreased, and the Johnsen score decreased significantly (P<0.05).The activities of acid phosphatase, alkaline phosphatase, lactate dehydrogenase, glutathione peroxidase (GPx), superoxide dismutase, catalase, and reduced glutathione all decreased significantly (P<0.05), and the level of malondialdehyde increased significantly (P<0.05). After intervention with resveratrol, compared with the Nano-TiO2 exposed group, the testicular and epididymal coefficients increased, semen quality and pathological tissue damage improved significantly (P<0.05), acid phosphatase and lactate dehydrogenase activities were significantly increased (P<0.05), and malondialdehyde levels in testicular tissue decreased significantly, while superoxide dismutase, glutathione peroxidase, and catalase activities increased significantly (P<0.05). After correlation analysis, it was found that there was a significant correlation between antioxidant enzymes and malondialdehyde and the indicators of semen quality and testicular function enzymes.
Resveratrol has a protective effect against reproductive toxicity induced by Nano-TiO2 in male mice.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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