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Based on the National Health and Nutrition Examination Survey (NHANES) database, this study investigates the association between the monocyte-to-albumin ratio (MAR) and all-cause and cardiovascular disease (CVD)mortality among individuals with diabetes mellitus.
Using NHANES 1999—2018 data linked to mortality outcomes from the National Death Index (NDI), we conducted a study among adults with diabetes mellitus. Weighted Cox proportional-hazards regression, Kaplan-Meier survival curves, restricted cubic spline regression, subgroup analyses, and interaction tests were employed to examine the associations of the monocyte-to-albumin ratio (MAR) with all-cause and CVD mortality among individuals with diabetes mellitus.
A total of 4 558 patients with diabetes mellitus were enrolled in this study. During follow-up, 1 250 all-cause deaths and 429 CVD-specific deaths were documented. MAR was categorized into tertiles. After adjusting for multiple confounding factors, compared with the lowest tertile group (Q1: MAR<0.011), the highest tertile group(Q3: MAR≥0.015) exhibited significantly increased risks of both all-cause mortality (HR=1.44, 95% CI: 1.21-1.71) and CVD mortality (HR=1.44; 95% CI: 1.01-2.05). Kaplan-Meier survival analysis demonstrated that the survival probability in the highest MAR tertile was markedly lower than that in the lowest tertile, with a statistically significant difference (P<0.001).
MAR is positively associated with both all-cause and CVD mortality in patients with diabetes and represents an independent risk factor for these outcomes.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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