Full
Outline
To investigate the characteristic changes and co-occurrence phenomenon of oral and intestinal fungal communities in children with asthma, and to explore the relationship between fungi and metabolism in asthma pathogenesis.
Thirty asthmatic children and thirty healthy controls were enrolled. Oral swabs and fecal samples were collected for metagenomic sequencing analysis of oral and intestinal fungal communities. Untargeted metabolomics was used to detect fecal metabolites. Multivariate statistical analysis and network models were employed to decipher microbe-metabolite associations.
Compared with healthy controls, asthmatic children showed significant alterations in α-diversity and β-diversity (Bray-Curtis distance) of oral and intestinal fungi. In the oral cavity, the relative abundance of genera such as Hanseniaspora and Jimgerdemannia was elevated, while that of genera such as Beauveria was reduced. In the gut, the relative abundance of the phylum Ascomycota was elevated, while genera such as Mucor showed a reduction in relative abundance. The co-occurrence network revealed shared fungi like Candida_f_Debaryomycetac along the oral-gut axis in the asthma group. Metabolomics identified significantly elevated ceramides and decreased α-linolenic acid and lysophosphatidylcholine in the asthmatic group,with Emmonsia showing a positive correlation with ceramides.
Altered oral-gut fungal community abundance and characteristic metabolic profile changes were associated with childhood asthma. The "oral-gut" co-occurrence of fungal communities may synergistically contribute to airway inflammation in conjunction with lipid metabolism dysregulation.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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