Full
Outline
To analyze the impact of low-density lipoprotein cholesterol (LDL-C) levels on all-cause mortality and cardio-cerebrovascular mortality in patients with hypertension and its comorbidities.
Univariate analyses were performed using the χ2 test, and Cox proportional hazards regression models were used to analyze the impact of LDL-C levels on the all-cause and cardio-cerebrovascular mortality risks of patients with hypertension and its comorbidities.
Multivariable Cox regression analysis showed that among patients with hypertension, compared with the first quartile group (Q1)of LDL-C, the risk of all-cause mortality increased by 75% in the third quartile group (Q3) and by 165% in the fourth quartile group (Q4), and the risk of cardio-cerebrovascular death increased by 96.4% in the Q4 group. Among the patients with comorbidities, the all-cause mortality risks of groups Q2, Q3, and Q4 were 1.601 times, 2.082 times, and 2.874 times that of group Q1, respectively. The cardio-cerebrovascular mortality risk of group Q4 was 2.592 times that of group Q1. The restricted cubic spline (RCS) model indicated that the LDL-C level was linearly correlated with the risk of all-cause and cardio-cerebrovascular death in patients with hypertension and its comorbidities. Among them, for patients with hypertension, the risk significantly increased when LDL-C exceeded 2.713 mmol/L (for all-cause mortality) and 2.650 mmol/L (for cardio-cerebrovascular mortality). For patients with comorbidities, the risk increased when LDL-C was higher than 2.016 mmol/L (for all-cause mortality) and 2.020 mmol/L (for cardio-cerebrovascular mortality).
Serum LDL-C levels are an independent risk factor for all-cause and cardio-cerebrovascular deaths in patients with hypertension and its comorbidities.This study reveals the dose-response relationship between LDL-C levels and mortality, providing an important scientific basis for more stringent lipid-lowering intervention strategies in clinical practice.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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