Full
Outline
To characterize the comorbidity profile of hepatitis C patients in Nanchang and evaluate its association with the efficacy of direct acting antivirals (DAAs) therapy.
We conducted a retrospective cohort study of 596 hepatitis C patients treated with DAAs in Nanchang between 2019 and 2024. Demographic data, comorbid conditions, and laboratory parameters were extracted from the hospital information system. The primary endpoint was sustained virological response 12 weeks post-treatment. Multivariable logistic regression models were used to examine the effect of comorbidities on treatment outcomes.
A total of 596 patients were included, with a mean age of 55.1±13.6 years, and 60.9% were male (363/596).The overall prevalence of comorbidities was 34.2% (204/596). The four most common comorbidities were hypertension (18.8%,112/596), liver cirrhosis (13.6%, 81/596), diabetes (7.4%, 44/596), and hepatitis B virus (HBV) co-infection (3.5%, 21/596).Multivariable analysis showed that the presence of comorbidities was independently associated with DAA treatment failure (aOR=2.68, 95% CI: 1.31-5.49). In terms of specific comorbidities, concurrent hepatitis B virus infection (OR=4.80, 95% CI: 1.65-14.78) and diabetes mellitus (OR=2.43, 95% CI: 1.09-5.30) were identified as independent risk factors for antiviral treatment failure.
Hepatitis C patients in Nanchang bear a substantial comorbidity burden, which independently compromises DAA efficacy. We recommend a multidisciplinary care model integrating hepatology and endocrinology to strengthen integrated management of comorbidities and improve antiviral outcomes.
24
13
| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
关闭全屏
No. 86 Xueyuan South Road, Haidian District, Beijing
010-62662699(Operation and Technical Support)
qkjq@cast.org.cn
Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House
