Full
Outline
To investigate the association between reproductive years and sarcopenia, and to assess the mediating role of depression in this relationship.
The study population was drawn from Hongguang Subdistrict, Pidu District, Chengdu City, Sichuan Province.Demographic data were collected through face-to-face interviews. Reproductive years were calculated based on the age at menarche and menopause. Muscle mass was assessed using the Inbody 770 analyzer, and grip strength and walking speed were measured to determine the presence of sarcopenia according to established guidelines. Multivariable logistic regression models were used to explore the association between reproductive years and sarcopenia. Mediation analysis was conducted to assess the mediating effect of depression on this association.
A total of 2 857 postmenopausal women were included in the final analysis. According to the Asian Working Group for Sarcopenia 2019 consensus on the diagnosis and treatment of sarcopenia, 1 098 participants (38.43%) were classified as having “possible sarcopenia”,463 (16.21%) as having “sarcopenia”, and 345 (12.08%) as having “severe sarcopenia”. Multivariable logistic regression showed that reproductive years were negatively associated with sarcopenia (OR=0.85, 95% CI: 0.75-0.96) and severe sarcopenia (OR=0.76, 95% CI: 0.67-0.85). Mediation analysis indicated that depression mediated the relationship between reproductive years and sarcopenia, with a mediation proportion of 9.67%. For severe sarcopenia, the mediation proportion was 6.34%.
Longer reproductive years are associated with a reduced risk of sarcopenia, and depression plays a mediating role in this association. Given the significant mediating effect of depression, more attention should be paid to the mental health of postmenopausal women to reduce the risk of sarcopenia potentially linked to low estrogen levels.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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