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Association of lifestyle-based oxidative balance score with the risk of obstructive sleep apnea syndrome
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Yuan YUAN1, Sen LIU1, Jing-ru MA1, Xiao-hua LV1, 2
Modern Preventive Medicine | 2026, 53(6) : 1099 - 1105
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Modern Preventive Medicine | 2026, 53(6): 1099-1105
• Health and Social Behavior •
Association of lifestyle-based oxidative balance score with the risk of obstructive sleep apnea syndrome
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Yuan YUAN1, Sen LIU1, Jing-ru MA1, Xiao-hua LV1, 2
Affiliations
  • West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China
Published: 2026-03-25 doi: 10.20043/j.cnki.MPM.202509078
Outline
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Objective

To investigate the association between the Lifestyle Oxidative Balance Score (Lifestyle-OBS) and the risk of developing obstructive sleep apnea syndrome (OSAS), and to provide evidence for lifestyle interventions targeting OSAS.

Methods

Adults aged 20 years and older from four survey cycles of the National Health and Nutrition Examination Survey (NHANES) 2005-2008 and 2015-2018 were included. Lifestyle-OBS was calculated based on physical activity, body mass index (BMI), smoking, and drinking behaviors. Weighted logistic regression models analyzed the association between lifestyle OBS and OSAS risk, with dose-response relationships assessed using restricted cubic splines. Subgroup analyses were conducted concurrently.

Results

A total of 5 368 individuals were included, among whom 3 601(67.09%) had OSAS. Weighted logistic regression analysis revealed that after adjusting for covariates, elevated Lifestyle-OBS was significantly negatively associated with the risk of OSAS (OR=0.801, 95% CI: 0.758-0.847). When Lifestyle-OBS was divided into four quartiles, the Q4 group had a reduced risk of OSAS compared with the Q1 group (OR =0.383, 95% CI: 0.288-0.510). Restricted cubic spline analysis revealed a linear negative-response association between Lifestyle-OBS and OSAS risk (Pfor nonlinearity=0.351). Subgroup analysis revealed significant interactions between Lifestyle-OBS and OSAS risk in age, hypertension, and cardiovascular disease subgroups. The association between Lifestyle-OBS and OSAS was stronger in younger and middle-aged individuals without hypertension or cardiovascular disease.

Conclusion

Higher Lifestyle-OBS is associated with a reduced risk of OSAS.

Obstructive sleep apnea syndrome  /  Lifestyle oxidative balance score  /  Oxidative stress  /  NHANES
袁源, 刘森, 马璟茹, 吕晓华. 生活方式氧化平衡评分与阻塞性睡眠呼吸暂停综合征的关联. 现代预防医学, 2026 , 53 (6) : 1099 -1105 . DOI: 10.20043/j.cnki.MPM.202509078
Yuan YUAN, Sen LIU, Jing-ru MA, Xiao-hua LV. Association of lifestyle-based oxidative balance score with the risk of obstructive sleep apnea syndrome[J]. Modern Preventive Medicine, 2026 , 53 (6) : 1099 -1105 . DOI: 10.20043/j.cnki.MPM.202509078
Appendix
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Year 2026 volume 53 Issue 6
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Article Info
doi: 10.20043/j.cnki.MPM.202509078
  • Receive Date：2025-09-04
  • Online Date：2026-11-02
  • Published：2026-03-25
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  • Received：2025-09-04
Affiliations
    West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China
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红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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