Full
Outline
To explore the mediating role of DNA methylation (DNAm) in the association between prenatal arsenic exposure and neonatal birth weight, and to identify DNAm-specific sites at different birth weight percentiles.
The data were obtained from the New Hampshire Birth Cohort Study (NHBCS), which included 270 mother-infant pairs. The quantitative correlation-based independent screening (QCSIS) method was combined with marginal quantitative regression analysis to identify DNA methylation (DNAm) sites associated with birth weight. After penalized estimation, the mediating effect analysis method was used to evaluate the mediating role of DNAm loci in the relationship between prenatal arsenic exposure and different birth weight percentiles.
After adjusting for maternal age, pre-pregnancy BMI, and other covariates, a total of 14 cytosine-phosphate-guanine pairs of nucleotides (CpG) sites with significant mediating effects were identified across 8 different birth weight quantiles. The eight birth weight percentiles were roughly divided into three groups: low, normal, and high birth weight, identifying 3, 3, and 8 CpG sites, respectively. The results showed that the cg17524924 site located in the ZNF542 gene significantly mediated the association between arsenic exposure and low birth weight (τ=0.3, ACME: -14.311，P=0.016) and (τ=0.4, ACME: -12.946, P=0.016); while the cg13486410 site located in the NDNF gene exhibited a positive mediating effect (τ=0.7, ACME: 14.041, P=0.030), suggesting that methylation at this site may partially offset the negative impact of prenatal arsenic exposure on neonatal birth weight.
This study finds that placental DNA methylation exerts quantile-specific mediating effects between arsenic exposure and neonatal birth weight. The results provide new insights into the mechanisms by which prenatal arsenic exposure affects fetal growth and development.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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