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The association between exercise and falls in elderly patients with chronic diseases: a chain mediation model based on cognitive function and depression
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Chen-shuai SHEN1, Wen-xiao YUAN1, Hong-ping LI1, Qian-qian GAO1, 3, Qi JING1, 3, Run-guo GAO2, 3, Hong-qing AN2, 3, Wei-qin CAI1, 3
Modern Preventive Medicine | 2025, 52(24) : 4538 - 4543
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Modern Preventive Medicine | 2025, 52(24): 4538-4543
• Health and Social Behavior •
The association between exercise and falls in elderly patients with chronic diseases: a chain mediation model based on cognitive function and depression
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Chen-shuai SHEN1, Wen-xiao YUAN1, Hong-ping LI1, Qian-qian GAO1, 3, Qi JING1, 3, Run-guo GAO2, 3, Hong-qing AN2, 3, Wei-qin CAI1, 3
Affiliations
  • School of Management, Shandong Second Medical University, Weifang, Shandong 261053, China
Published: 2025-12-25 doi: 10.20043/j.cnki.MPM.202508052
Outline
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Objective

To investigate cognitive function and depression as mediators between exercise and falls in elderly chronic disease patients.

Methods

Using stratified and convenience sampling, this cross-sectional survey in Shandong included 1 433 elderly chronic disease patients via a self-designed questionnaire. Generalized structural equation modeling and Bootstrap testing were used.

Results

Fall incidence was 18.8%. Exercisers had significantly lower fall incidence. Cognitive function scores were lower in fallers; depression scores were higher in fallers. Exercise, cognitive function, and depression significantly affected falls (P<0.05). Exercise negatively predicted falls (β=-0.376, 95% CI:-0.685- -0.067). Cognitive function (β=-0.037, 95% CI:-0.070--0.004) and depression (β=-0.124, 95% CI:-0.194- -0.055) had significant mediating effects. A chain-mediating effect existed via cognitive function and depression (β=-0.011, 95% CI:-0.021--0.001).

Conclusion

Exercise directly reduces falls and also reduces falls indirectly through the mediating effects of cognitive function and depression.

Exercise  /  Falls  /  Cognitive function  /  Depressive
沈辰帅, 袁文筱, 李红萍, 高倩倩, 井淇, 高润国, 安洪庆, 蔡伟芹. 运动锻炼与老年慢性病患者跌倒的关系:基于认知功能和抑郁的链式中介作用. 现代预防医学, 2025 , 52 (24) : 4538 -4543 . DOI: 10.20043/j.cnki.MPM.202508052
Chen-shuai SHEN, Wen-xiao YUAN, Hong-ping LI, Qian-qian GAO, Qi JING, Run-guo GAO, Hong-qing AN, Wei-qin CAI. The association between exercise and falls in elderly patients with chronic diseases: a chain mediation model based on cognitive function and depression[J]. Modern Preventive Medicine, 2025 , 52 (24) : 4538 -4543 . DOI: 10.20043/j.cnki.MPM.202508052
Appendix
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Year 2025 volume 52 Issue 24
26
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Article Info
doi: 10.20043/j.cnki.MPM.202508052
  • Receive Date：2025-08-04
  • Online Date：2026-11-02
  • Published：2025-12-25
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  • Received：2025-08-04
Funding
Affiliations
    School of Management, Shandong Second Medical University, Weifang, Shandong 261053, China
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表12种不同金属材料的力学参数
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Number of
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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