Full
Outline
To investigate the association and dose–response relationship between leisure-time physical activity (LTPA) and the risk of incident common mental disorders.
This study included 388 559 participants without a history of mental disorders at baseline from the UK Biobank cohort. Weekly total energy expenditure from LTPA was calculated and categorized into four groups: inactive (0MET-h/week), insufficiently active (>0–7.49MET-h/week), sufficiently active (7.5–14.9MET-h/week), and highly active (≥15MET-h/week). Multivariable Cox proportional hazards models were used to calculate hazard ratios ( HR), and restricted cubic splines were applied to explore the dose–response patterns.
During a median follow-up of 12.71 years, 27 875 incident cases of mental disorders were documented. Compared with the inactive group, the risk of mental disorders was significantly reduced in the below recommended, meeting recommended, and above recommended groups, with HR of 0.84 (95% CI: 0.81–0.87), 0.76 (95% CI: 0.72–0.79), and 0.73 (95% CI: 0.70–0.76), respectively. Restricted cubic spline analysis demonstrated an L-shaped nonlinear association. LTPA was inversely associated with the risk of depression, anxiety disorders, and schizophrenia, while no significant associations were found for bipolar disorder or eating disorders.
LTPA is significantly inversely associated with the risk of developing mental disorders. Protective effects were observed even at activity levels below current recommendations, and a clear dose–response relationship was evident.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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