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Active surveillance of adverse reactions following vaccination with meningococcal polysaccharide conjugate vaccine (groups A, C, Y, and W135) in Luohu District, Shenzhen
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Xi-dan WANG1, Kai HUANG1, Chun-ying LAI2, Chuan-de CHEN1
Modern Preventive Medicine | 2026, 53(11) : 2088 - 2094
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Modern Preventive Medicine | 2026, 53(11): 2088-2094
• Disease Control and Prevention •
Active surveillance of adverse reactions following vaccination with meningococcal polysaccharide conjugate vaccine (groups A, C, Y, and W135) in Luohu District, Shenzhen
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Xi-dan WANG1, Kai HUANG1, Chun-ying LAI2, Chuan-de CHEN1
Affiliations
  • Department of Infectious Disease Prevention and Control, Luohu District Center for Disease Control and Prevention, Shenzhen, Guangdong 518020, China
Published: 2026-06-10 doi: 10.20043/j.cnki.MPM.202601265
Outline
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Objective

To evaluate the incidence of adverse reactions in age-eligible people after post-marketing vaccination with the groups A, C, Y, and W135 meningococcal polysaccharide conjugate vaccine (MPCV-ACYW135).

Methods

Individuals who received MPCV-ACYW135 vaccination were recruited in Luohu District, Shenzhen. Active surveillance was conducted to collect adverse reactions occurring within 0-30 days after vaccination, and the incidence of adverse reactions was analyzed.

Results

A total of 468 participants were enrolled. The overall incidence of adverse reactions post-vaccination was 25.64%. The incidences of local reactions and systemic reactions were 12.39% and 18.38% (χ2=23.356, P<0.001), respectively. The overall incidences of grade 1, 2, and 3 adverse reactions were 14.53%, 10.68%, and 0.43% (χ2=63.639, P<0.001), and no grade 4 adverse reactions were observed. The incidences of adverse reactions at <30 minutes and 30 minutes - 24 hours after vaccination were 7.69% and 17.95% (χ2=97.099, P<0.001).

Conclusion

The incidence of adverse reactions within 30 days after MPCV-ACYW135 vaccination in the study population was consistent with the results of pre-marketing clinical trials. Adverse reactions were mainly mild to moderate, and most occurred within 24 hours after vaccination, indicating that the vaccine has good safety.

Meningococcal polysaccharide conjugate vaccine (groups A, C, Y, and W135)  /  Vaccination  /  Adverse reactions  /  Active surveillance
王希丹, 黄凯, 赖春颖, 陈传德. 深圳市罗湖区ACYW135群脑膜炎球菌多糖结合疫苗预防接种不良反应主动监测结果分析. 现代预防医学, 2026 , 53 (11) : 2088 -2094 . DOI: 10.20043/j.cnki.MPM.202601265
Xi-dan WANG, Kai HUANG, Chun-ying LAI, Chuan-de CHEN. Active surveillance of adverse reactions following vaccination with meningococcal polysaccharide conjugate vaccine (groups A, C, Y, and W135) in Luohu District, Shenzhen[J]. Modern Preventive Medicine, 2026 , 53 (11) : 2088 -2094 . DOI: 10.20043/j.cnki.MPM.202601265
Appendix
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Year 2026 volume 53 Issue 11
26
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Article Info
doi: 10.20043/j.cnki.MPM.202601265
  • Receive Date：2026-01-18
  • Online Date：2026-11-02
  • Published：2026-06-10
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  • Received：2026-01-18
Funding
Affiliations
    Department of Infectious Disease Prevention and Control, Luohu District Center for Disease Control and Prevention, Shenzhen, Guangdong 518020, China
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表12种不同金属材料的力学参数
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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