Full
Outline
To investigate the association between the comprehensive dietary antioxidant index (CDAI) and the homeostatic model assessment of insulin resistance (HOMA-IR), and to evaluate the mediating effect of obesity in this association.
Data were derived from the 2005—2018 National Health and Nutrition Examination Survey (NHANES). CDAI was calculated via 24-hour dietary recalls. Weighted multivariable linear regression and restricted cubic splines were used to analyze the association between CDAI and HOMA-IR, while mediation analysis assessed the potential role of obesity.
A total of 2 568 participants were included in this study. After fully adjusting for confounding factors, weighted multivariable linear regression analysis revealed a negative association between CDAI and HOMA-IR levels (β=-0.05, 95% CI: -0.07~-0.02, P<0.001). Compared with the lowest quartile of CDAI, the highest quartile showed a reduction in HOMA-IR levels (β=-0.39, 95% CI:-0.67~-0.12, P=0.007). Mediation analysis indicated that obesity had no significant mediating effect on this association (P=0.28).
Higher CDAI levels are independently associated with lower HOMA-IR. The absence of a significant mediating effect of obesity suggests that the protective effect of CDAI may be achieved through direct biological pathways, such as reducing oxidative stress and improving insulin signaling, independent of body weight. Further longitudinal studies are warranted to verify causality.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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