Full
Outline
To investigate the associations of monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) with mitochondrial DNA copy number (mtDNA-CN) and telomere length (TL) in an arsenic-exposed population.
A cross-sectional study was conducted involving 78 workers from a coke oven plant and their fellow villagers from the same village in Southern Yunnan Province,China. Questionnaire surveys and biological sample collection were performed. Concentrations of inorganic arsenic (iAs), MMA, and DMA in urine were determined using hydride generation-flame atomic absorption spectrometry. mtDNA-CN and TL were measured by quantitative real-time polymerase chain reaction (PCR). Multiple linear regression analysis was performed with mtDNA-CN and TL as dependent variables and log-transformed iAs, MMA, and DMA as independent variables.
After adjusting for confounders in the multiple linear regression model, MMA showed a significant positive association with mtDNA-CN (, P=0.017), while DMA showed a significant negative association (
, P=0.007). To address potential multicollinearity and assess model stability, the relationships of arsenic methylation indices, including the primary methylation index (PMI) and secondary methylation index (SMI), with mtDNA-CN were further analyzed. The results showed that PMI was significantly negatively associated with mtDNA-CN (
, P=0.041), whereas SMI showed no significant association. Furthermore, no statistically significant associations were observed between MMA or DMA and TL(P>0.05).
A negative correlation was observed between PMI and mtDNA-CN during arsenic metabolism. This may be attributed to the combined effects of arsenic-induced mitochondrial oxidative stress damage and potential insufficiency in mtDNA synthesis resulting from the disproportionate allocation of methyl resources due to highly active arsenic methylation.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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