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Long-term effects of adverse childhood experiences on depression symptoms in middle-aged and older adults: the mediating role of social isolation
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Qiu-li ZHU, Jun-qing LUO, Zi-xian HUANG, Ruo-yu GUI, Gang SUN
Modern Preventive Medicine | 2026, 53(10) : 1817 - 1822
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Modern Preventive Medicine | 2026, 53(10): 1817-1822
• Primary Health Services •
Long-term effects of adverse childhood experiences on depression symptoms in middle-aged and older adults: the mediating role of social isolation
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Qiu-li ZHU, Jun-qing LUO, Zi-xian HUANG, Ruo-yu GUI, Gang SUN
Affiliations
  • School of Health Management, Southern Medical University, Guangzhou, Guangdong 510515, China
Published: 2026-05-25 doi: 10.20043/j.cnki.MPM.202512110
Outline
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Objective

To investigate the role of social isolation in the long-term impact of adverse childhood experiences (ACEs) on depressive symptoms in middle-aged and older adults, and to provide empirical support for preventing and intervening in the negative effects of ACEs on mental health in this population.

Methods

Based on data from the 2014 life history survey and the 2018 and 2020 follow-up survey of the China Health and Retirement Longitudinal Study (CHARLS), a total of 12 695 middle-aged and older adults aged ≥45 years were included. ACEs were derived from the 2014 data, social isolation from the 2018 data, and depressive symptoms from the 2020 data. The relationships among social isolation, ACEs, and depressive symptoms were examined using independent samples t-tests, chi-square tests, and Pearson correlation analysis. The mediating effect of social isolation between ACEs and depressive symptoms was analyzed through mediation models, Sobel tests, and bootstrap tests.

Results

ACEs showed a significant positive correlation with depressive symptoms (β=0.618, P<0.001). Path analysis revealed that social isolation partially mediated the association between ACEs and depressive symptoms. Specifically, ACEs positively predicted social isolation (β=0.026, P<0.001), and social isolation positively predicted depressive symptoms (β=0.913, P<0.001). Both Sobel and Bootstrap tests confirmed the robustness of this mediating effect. The influence of ACEs and social isolation on depressive symptoms was consistent across different genders and age groups within the middle-aged and elderly population.

Conclusion

ACEs can directly or indirectly influence depressive symptoms in middle-aged and older adults through the mediating effect of social isolation. Relevant social departments should implement life-course intervention strategies, including preventing ACEs, providing psychological counseling, and building social support networks, to alleviate depression issues among middle-aged and older adults.

Adverse childhood experiences  /  Depressive symptoms  /  Social isolation  /  Middle-aged and older adults  /  Mediating effect
朱秋黎, 骆俊卿, 黄子娴, 桂若羽, 孙刚. 童年不良经历对中老年抑郁症状的长期影响——社会隔离的中介效应. 现代预防医学, 2026 , 53 (10) : 1817 -1822 . DOI: 10.20043/j.cnki.MPM.202512110
Qiu-li ZHU, Jun-qing LUO, Zi-xian HUANG, Ruo-yu GUI, Gang SUN. Long-term effects of adverse childhood experiences on depression symptoms in middle-aged and older adults: the mediating role of social isolation[J]. Modern Preventive Medicine, 2026 , 53 (10) : 1817 -1822 . DOI: 10.20043/j.cnki.MPM.202512110
Year 2026 volume 53 Issue 10
23
13
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doi: 10.20043/j.cnki.MPM.202512110
  • Receive Date:2025-12-06
  • Online Date:2026-11-02
  • Published:2026-05-25
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  • Received:2025-12-06
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    School of Health Management, Southern Medical University, Guangzhou, Guangdong 510515, China
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表12种不同金属材料的力学参数
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Family
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Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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