Full
Outline
To explore the association between accelerated phenotypic aging(PAA) and risk of osteoarthritis(OA), and to assess the modifying effect of genetic susceptibility, as well as the mediating effect of body mass index(BMI) on the PAA-OA association.
Using baseline survey, diagnostic, and genetic data from the UK Biobank(UKB), Cox proportional hazards regression models was employedto analyze the association between PAA and OA, and pathway analysis was employed to explore the mediating effect of BMI.
With an average follow-up of 13.7 years, a total of 42 977 incident OA cases were recorded. PAA acceleration was significantly associated with an increased risk of OA(HR=2.13, 95%CI:2.11-2.15). BMI mediated 77.1%(95%CI:65.5%-92.1%) of the total effect. Further subgroup analyses revealed that the PAA-OA association was significant across all subgroups, including different sex, age, and BMI levels. No gene-PAA interaction was identified for OA risk.
PAA is an independent risk factor for OA, and BMI is an important mediating variable in the PAA-OA association. This study provides novel insights and public health implications for delaying aging and preventing OA.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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