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Outline
To explore the mediating role of sleep quality in the relationship between multimorbidity and depressive symptoms in patients with pneumoconiosis.
Based on the baseline data from the West China Pneumoconiosis Prospective Specialized Disease Cohort, latent class analysis was employed to categorize nine common multimorbidities among pneumoconiosis patients. Logistic regression models were used to analyze the associations between the number of multimorbidities, multimorbidity patterns, and depressive symptoms. The Bootstrap method was employed to examine the mediating effect of sleep quality.
40.97% patients with pneumoconiosis exhibited depressive symptoms. Latent class analysis identified four multimorbidity patterns: relatively healthy, cardiovascular-metabolic, respiratory system, and multimorbidity. Logistic regression showed that the number of multimorbidities (OR=1.34, 95%CI: 1.23-1.46), the cardiovascular-metabolic pattern (OR=1.82, 95%CI: 1.02-3.25), and the multimorbidity pattern (OR=3.16, 95%CI: 1.97-5.06) were positively associated with depressive symptoms. Mediation analysis indicated that sleep quality partially mediated the relationship between the number of multimorbidities and depressive symptoms (β=0.53, 95%CI: 0.41-0.66), with a mediation effect proportion of 61.63%. Regarding the multimorbidity pattern, sleep quality fully mediated the relationship with depressive symptoms, with a mediation effect value of 2.11(95%CI:1.46-2.78) and an effect proportion of 69.41%.
The number of multimorbidities, cardiovascular-metabolic pattern, and multimorbidity pattern are associated with a higher risk of depression in pneumoconiosis patients. Sleep quality partially mediates the relationship between the number of multimorbidities and depressive symptoms, while it fully mediates the relationship between the multimorbidity pattern and depressive symptoms.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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