Full
Outline
To investigate the association between the serum uric acid to albumin ratio (UAR) and hypertension.
This study included data from 23 552 U.S. adults from the NHANES database(2007—2016). Multivariable logistic regression models and smooth curve fitting were used to examine the linear and nonlinear relationships between UAR and hypertension. Threshold effect analysis was applied to identify inflection points, and subgroup analyses were conducted to assess the association across different populations. Finally, the diagnostic performance of UAR for hypertension was evaluated using receiver operating characteristic(ROC) curves.
After adjusting for all confounding factors, multivariable logistic regression analysis showed that higher UAR was significantly associated with an increased prevalence of hypertension (OR=1.11, 95% CI: 1.09-1.13). Compared with the low UAR group, the middle (OR=1.14, 95% CI: 1.05-1.24) and high (OR=1.46, 95% CI: 1.33-1.60) UAR groups had significantly increased risks of hypertension(P<0.05). Smooth curve fitting revealed a J-shaped nonlinear relationship between UAR and hypertension. Threshold effect analysis indicated that below the threshold of 4.66, UAR was negatively correlated with hypertension (OR=0.75, 95% CI: 0.61-0.92), whereas above 4.66, a positive correlation was observed (OR=1.12, 95% CI: 1.10-1.14). Consistent results were obtained in subgroup analyses, and interaction effects were observed across subgroups stratified by sex, age, alcohol consumption, BMI, and diabetes (P<0.05). The ROC curve demonstrated that UAR had moderate predictive ability for hypertension, with an area under the curve (AUC) of 0.639.
UAR is closely associated with hypertension and may serve as a promising biomarker for assessing early hypertension risk.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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