Full
Outline
To investigate the correlation between the C-reactive protein-albumin-lymphocyte（CALLY）index and chronic obstructive pulmonary disease（COPD）.
Using data from two cycles of the National Health and Nutrition Examination Survey（NHANES）in the United States from 2015 to March 2020, we conducted multivariate logistic regression, subgroup analysis, and restricted cubic spline analysis to explore the relationship between Log2CALLY and COPD. The predictive accuracy of Log2CALLY for COPD risk was assessed using receiver operating characteristic（ROC）curve analysis.
A total of 7 186 participants were included in this study, of whom 817（10.89%）had COPD. Multivariate logistic regression revealed that the prevalence of COPD in the highest quartile group was 40% lower compared to the lowest quartile group（OR=0.60, 95% CI:0.39-0.94, P=0.029）. Restricted cubic spline analysis confirmed a linear negative correlation between Log2CALLY and COPD（Pnon-linear=0.74）. No significant interactions were observed between age, gender, body mass index, smoking and drinking status, hypertension, diabetes, asthma, cardiovascular disease, and Log2CALLY（P>0.05）. ROC curve analysis demonstrated that after full adjustment, the area under the curve（AUC）for Log2CALLY in predicting COPD risk was 0.83.
The CALLY index is linearly negatively correlated with the risk of COPD, indicating its potential as a composite biomarker for early risk prediction of COPD.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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