Full
Outline
To explore the impact of arthritis, depression and their interaction on the disability risk in Chinese elderly.
Using data from the China Health and Retirement Longitudinal Study (CHARLS), eligible participants were enrolled, and 2015 baseline data and incident disability during the 5-year follow-up were collected. Multivariable cox regression models were established to analyze the effects of arthritis and depression on disability risk among Chinese elderly and to assess, on the multiplicative and additive scales, the impact of their interaction on disability risk.
A total of 7 875 participants were included, and 586 new cases of disability occurred during the 5-year follow-up period, with an incidence rate of 7.4%.The multivariable cox regression analysis showed that arthritis (HR=1.92, 95% CI: 1.63-2.26) and depression (HR=2.65, 95% CI: 2.22-3.16) were both risk factors for disability. The interaction analysis showed that there was no multiplicative interaction between arthritis and depression on the disability risk (P>0.05), but there was an additive interaction effect (P<0.05), with the relative excess risk due to interaction (RERI) of 1.08 (95% CI: 0.32-1.85), the attributable proportion of interaction (AP) of 0.26 (95% CI: 0.09-0.42), and the synergy index (SI) of 1.51 (95% CI: 1.09-2.08).
Both arthritis and depression are risk factors for disability in Chinese elderly, and there is an additive interaction between them. We should pay more attention to elderly people with comorbid arthritis and depression and take active measures to reduce the disability risk in Chinese elderly.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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