Full
Outline
To summarize the levels of vitamin D in patients with common ocular diseases and explore the relationship between low vitamin D levels and the occurrence of ocular diseases.
A search was conducted in the PubMed, Web of Science, Embase, and Cochrane databases up to May 25, 2024, to collect meta-analysis studies assessing the relationship between vitamin D and ocular diseases. Additionally, observational studies not included in existing meta-analyses were collected, and the effect size and 95% confidence interval (CI) were calculated using the random effects weighted mean difference (WMD). The results of the studies were included in the meta-analysis, culminating in an umbrella review.
This study included 13 meta-analyses and 15 observational studies (11 case-control studies and 4 cross-sectional studies). The meta-analysis indicated that the overall weighted mean difference (WMD) for vitamin D and ocular diseases was -2.17 (95%CI: -2.50 to -1.84; P=0.282, I2=18.7%). The overall odds ratio (OR) for vitamin D in ocular diseases was 0.96 (95%CI: 0.92 to 0.99; P<0.001, I2=87.1%). The robustness of the conclusions was verified through trial sequential analysis (TSA).
Higher vitamin D levels are significantly associated with a reduced risk of developing glaucoma and myopia, yet showing an association with an increased risk of non-infectious uveitis (NIU).
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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