Full
Outline
To evaluate the association between gestational diabetes mellitus (GDM) and genitourinary tract infections during pregnancy (GUTIs) through retrospective analysis and Mendelian randomization (MR) analysis.
A retrospective analysis was conducted on 7 751 pregnant women who underwent prenatal check-ups and delivered between 2020 and 2022, comparing the rates of GUTIs between women with GDM and those without. Additionally, data from genome-wide association studies (GWAS) were selected, and the inverse-variance weighted (IVW) method was employed as the primary analytical approach, supplemented by weighted median (WM), weighted mode (WM), and MR-Egger regression methods. Sensitivity analyses were performed using MR-Egger regression, Cochran’s Q test, and leave-one-out analysis to investigate the causal relationship between GDM and GUTIs.
Both univariate chi-square tests (P=2.2×10-16) and multivariate stepwise logistic regression analyses (P=2×10-16) revealed a significant correlation between GDM and GUTIs. The two-sample MR study further confirmed a significant association between the two (IVW: β=0.211, P=0.013). The MR-Egger regression method did not indicate significant horizontal pleiotropy (P=0.813), and leave-one-out analysis and Cochran’s Q test showed no significant heterogeneity among all SNPs (P=0.876, P=0.938).
The presence of GDM may increase the risk of GUTIs. Effective screening and management of GDM patients could help reduce and prevent GUTIs.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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