Full
Outline
To investigate the shared genetic structure between six autoimmune diseases (AIDs) and ten psychiatric disorders (PDs) using Genome Structural Equation Modeling (GSEM) and Mendelian randomization (MR).
The research employed linkage disequilibrium score regression to assess the genetic correlations between diseases. GSEM was introduced for exploratory factor analysis on odd-numbered chromosomes and confirmatory factor analysis on even-numbered chromosomes for cross-validation, along with path analysis to establish a three-factor model and hierarchical model.Additionally, a multivariable genome-wide association study was conducted on latent factors to test the bidirectional causal relationships between mediating variables and factors, thereby revealing the complex genetic relationships among the diseases.
GSEM results indicated that the selected 16 diseases could be explained by a three-factor model consisting of three independent factors, which fitted the research data best (χ2=865.291, AIC=929.291, CFI=0.940, SRMR=0.097). In this model, Factor 1 and Factor 3 exhibited characteristics closely related to autoimmune diseases, while Factor 2 primarily encompassed psychiatric disorders, with scleroderma serving as a mediating variable linking the two types of diseases. MR results revealed a bidirectional causal effect between scleroderma and Factor 2 and Factor 3.
GSEM and MR can be utilized to uncover the shared genetic structure and causal effects between AIDs and PDs, thereby highlighting their interactions and providing an important methodological tool for understanding the genetic relationships among complex diseases.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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