Full
Outline
To evaluate the long-term cost-effectiveness of a Mediterranean diet compared with a conventional low-fat diet for the secondary prevention of coronary heart disease (CHD) in China.
Based on the clinical data from the CORDIOPREV trial, we developed a decision-tree Markov model to estimate the total costs and quality-adjusted life years(QALYs) associated with two dietary interventions from a societal perspective. Finally, the incremental cost-effectiveness ratio(ICER) and incremental net monetary benefit (INMB) were calculated. The willingness-to-pay (WTP) threshold was set at 1-3 times China’s per capita GDP in 2024. Model robustness was tested with one-way and probabilistic sensitivity analyses.
Over 20 years, the Mediterranean diet group incurred a cumulative total cost of 534 194.73 yuan per patient and gained 9.89 QALYs, whereas the low-fat diet group incurred a total cost of 466 877.72 yuan per patient and gained 9.55 QALYs. The ICER was 196 360.67 yuan/QALY, between 1 and 3 times the per capita GDP. At a threshold of three times China’s per capita GDP, the INMB was 31 071.64, and probabilistic sensitivity analysis demonstrated that the Mediterranean diet had a 57.68%probability of being cost-effective.
The Mediterranean diet is more cost-effective than the low-fat diet for secondary prevention of CHD in China, supporting its inclusion in secondary prevention strategies for CHD in China.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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