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This study aims to investigate the association between an inflammatory score constructed from white blood cell (WBC) count and high-sensitivity C-reactive protein (hs-CRP) and the risk of type 2 diabetes mellitus (T2DM).
Using data from the China Health and Retirement Longitudinal Study (CHARLS) and the U.S. National Health and Nutrition Examination Survey (NHANES), this study performed logistic regression analyses, restricted cubic spline (RCS) analyses, and subgroup analyses to investigate the association between the WBC-hsCRP inflammatory score and T2DM.
Logistic regression analyses indicated that higher WBC-hsCRP inflammatory scores were associated with increased odds of T2DM.After extensive adjustment for potential confounders, each interquartile-range (IQR) increase in the WBC-hsCRP inflammatory score was associated with a 12% and 45% higher odds of T2DM in CHARLS and NHANES, respectively (CHARLS: OR=1.12,95% CI: 1.05-1.19; NHANES: OR=1.45, 95% CI: 1.22-1.72). RCS analyses suggested a nonlinear association in CHARLS but an approximately linear association in NHANES. The robustness of these findings was further confirmed by subgroup analyses.
Our results indicate a positive association between the WBC-hsCRP inflammatory score and T2DM, suggesting its potential utility for identifying individuals at elevated risk of T2DM.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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