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Effects of butylparaben on intestinal microbiota in zebrafish
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Hui YANG1, 3, Meng ZHAO1, 3, Xuan CHEN1, 3, Si-min WANG1, 3, Jia-qi GU1, 3, Si-ying LI1, 3, Ran LU2, 3, Luo YANG1, 2, 3
Modern Preventive Medicine | 2026, 53(15) : 2847 - 2853
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Modern Preventive Medicine | 2026, 53(15): 2847-2853
• Experimental Technology and Application •
Effects of butylparaben on intestinal microbiota in zebrafish
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Hui YANG1, 3, Meng ZHAO1, 3, Xuan CHEN1, 3, Si-min WANG1, 3, Jia-qi GU1, 3, Si-ying LI1, 3, Ran LU2, 3, Luo YANG1, 2, 3
Affiliations
  • West China School of Public Health/West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China
Published: 2026-08-10 doi: 10.20043/j.cnki.MPM.202604196
Outline
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Objective

To investigate the effects of subchronic exposure to butylparaben (BuP) on the gut microbiota of adult male zebrafish.

Methods

Four-month-old wild-type AB male zebrafish were randomly divided into a solvent control group(NC), a 2.5 μM BuP group, and a 5 μM BuP group, with 15 fish per group. After 60 days of subchronic exposure, intestinal tissues and contents were collected. Gut microbial diversity, community structure, and functional pathways were analyzed using 16S rRNA high-throughput sequencing.

Results

Compared with the NC group, BuP exposure significantly decreased Chao1,ACE, Simpson, and Shannon indices (all P<0.001). β-diversity revealed distinct separation of microbial community structure.At the phylum level, the relative abundance of Fusobacteriota was increased (P<0.001), while Proteobacteria and Actinobacteriota were decreased (P<0.001). At the genus level, Cetobacterium, Aeromonas, and Plesiomonas were enriched (P<0.001), whereas f_Rhodobacteraceae_unclassified and Pedomicrobium were reduced (P<0.001). Functional prediction indicated that BuP exposure disturbed microbial metabolic pathways, including lipid metabolism and immune regulation.

Conclusion

Subchronic BuP exposure reduces gut microbial diversity, reshapes community structure, impairs metabolic function, and disrupts intestinal microecological homeostasis in zebrafish.

Butylparaben  /  Zebrafish  /  Gut microbiota
杨慧, 赵萌, 陈璇, 王思敏, 顾嘉奇, 李思颖, 陆然, 杨罗. 对羟基苯甲酸丁酯对斑马鱼肠道微生物的影响. 现代预防医学, 2026 , 53 (15) : 2847 -2853 . DOI: 10.20043/j.cnki.MPM.202604196
Hui YANG, Meng ZHAO, Xuan CHEN, Si-min WANG, Jia-qi GU, Si-ying LI, Ran LU, Luo YANG. Effects of butylparaben on intestinal microbiota in zebrafish[J]. Modern Preventive Medicine, 2026 , 53 (15) : 2847 -2853 . DOI: 10.20043/j.cnki.MPM.202604196
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Year 2026 volume 53 Issue 15
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Article Info
doi: 10.20043/j.cnki.MPM.202604196
  • Receive Date：2026-04-15
  • Online Date：2026-09-28
  • Published：2026-08-10
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  • Received：2026-04-15
Funding
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    West China School of Public Health/West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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