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Outline
To explore the associations of nine indices related to insulin resistance, lipid metabolism, and obesity,including estimated glucose disposal rate (eGDR), triglyceride glucose index (TyG), metabolic score for insulin resistance(METS-IR), triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C ratio), TyG-waist circumference (TyG-WC),TyG-body mass index (TyG-BMI), TyG-waist-to-height ratio (TyG-WHtR), a body shape index (ABSI), and conicity index(CI), with hyperuricemia (HUA) among middle-aged and elderly individuals in a county in Guangxi, to screen for key indicators, and to validate them through a cohort study.
A combined cross-sectional and prospective cohort study design was employed. Multivariable logistic regression analysis was used to evaluate the association between each index and HUA. Five machine learning models, including XGBoost, were constructed to evaluate the performance of these indices and screen for key indices. In the prospective cohort, modified Poisson regression and restricted cubic splines (RCS) were utilized to analyze the association and dose-response relationship between the most critical index and the risk of incident HUA.
Multivariable logistic regression showed that after adjusting for covariates, TyG, METS-IR, TG/HDL-C ratio, TyG-WC, TyG-BMI, TyG-WHtR, ABSI, and CI were positively associated with HUA, whereas eGDR was negatively associated with HUA (P<0.001). The machine learning model results indicated that the TG/HDL-C ratio was the most critical index for identifying HUA.A non-linear association was observed between the TG/HDL-C ratio and the risk of incident HUA (P<0.001), with a threshold of 2.971 for the TG/HDL-C ratio in relation to HUA.
All nine indices were associated with HUA in middle-aged and elderly people. The TG/HDL-C ratio was the most critical index for identifying HUA, which holds important public health significance for the early identification of individuals with hyperuricemia.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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