Full
Outline
To analyze the trends in disease burden of HIV/AIDS in China from 1990 to 2023 and conduct a death attribution analysis, providing evidence for refining national HIV prevention and control strategies.
Utilizing data from the Global Burden of Disease Study 2023, the age-standardized incidence rate, mortality rate and disability-adjusted life years (DALYs) rate were applied to assess the disease burden of HIV/AIDS in China. The Joinpoint regression model was used to calculate the annual percent change (APC) and average annual percent change (AAPC). The age-period-cohortmodel was applied to examine the effects of age, period, and birth cohort in disease burden. Death attribution analyses were performed for comorbidities such as tuberculosis (TB).
The age-standardized incidence rate of HIV/AIDS in China increased from 0.69 per 100 000 in 1990 to 2.36 per 100 000 in 2023, with an AAPC of 3.78%. The age-standardized mortality rate rose from 0.14 per 100 000 in 1990 to 1.65 per 100 000 in 2023, with an AAPC of 7.71%. The age-standardized DALYs rate increased from 6.81 per 100 000 in 1990 to 78.21 per 100 000 in 2023, with an AAPC of 7.70%. Age-period-cohort model analysis revealed a “bimodal” age distribution in incidence, with peaks among the 20-34 and over-70 age groups. Compared with the period 2004-2008, the risk of incidence showed a declining trend after 2008, while the risk of mortality and DALYs increased. All indicators showed higher risks in males than in females. Compared with 1955-1959 birth cohort, the highest incidence risk was observed in the 1930-1934 birth cohort, while individuals born after 1960 showed increasing risks of death and DALYs. In terms of death attribution, deaths due to other diseases caused by HIV increased from 55.38% in 1990 to 93.33% in 2023. TB-related deaths continued to decline, predominantly involving HIV-drug-susceptible tuberculosis (HIV-DS-TB), with a higher proportion among males.
From 1990 to 2023, the disease burden of HIV/AIDS in China showed an upward trend. Young adults aged 20-34 yearsandthe elderly are key priority populations. Non-tuberculosis-related-diseases have become the leading cause of death. Future prevention and control strategies in China should focus on interventions targeting sexual transmission, early detection and treatment for young adults, the elderly, and male populations, as well as enhanced surveillance and management of non-tuberculosis-related-diseases.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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