Full
Outline
To evaluate the effectiveness of community-based management program involving second-generation antipsychotic long-acting injectables (SGA-LAIs) for patients with severe mental disorders (SMD).
Based on the Sichuan Provincial Severe Mental Disorders Management System, patients enrolled in the program between April 2022 and February 2023 were selected. Clinical symptoms and social functioning were assessed using the Positive and Negative Syndrome Scale (PANSS) and the Social Disability Screening Schedule (SDSS). Caregiver burden was measured using the Zarit Burden Interview (ZBI). A linear mixed-effects model (LMM) was applied to handle the unbalanced longitudinal data and analyze the trends of each indicator over time.
A total of 1 740 patients with severe mental disorders were included. During follow-up, the total PANSS score, its subscale scores, and the total SDSS score all showed significant decreasing trends over time (P<0.001). Age was positively correlated with both PANSS and SDSS scores (P<0.05), and female patients had more severe social functional impairment (β=0.435, P=0.009).
The community-based management program incorporating SGA-LAIs isassociated with sustained improvement in patients’ symptoms and functioning, as well as a reduction in caregiver burden. The results suggest a need for attention to personalized support for older adults and female patients. Given the study design limitations, the causal effect of the observed associations requires verification by future controlled studies.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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