Full
Outline
To investigate the association between memory decline and the risk of incident stroke among middle-aged and older adults in China.
Using data from the China Health and Retirement Longitudinal Study (CHARLS), individuals without stroke at baseline were enrolled and followed from 2013 to 2018 to monitor stroke occurrence. Baseline memory status was assessed via subjective memory evaluation, objective memory scores, and history of memory-related diseases.Multivariable Cox regression models were employed to evaluate the association between memory decline and stroke incidence.
The study cohort comprised 14 886 participants.Over an average follow-up of 6.19 years, a total of 893 incident stroke events were recorded, with a 6-year cumulative incidence of 6.0%. After adjusting for demographics, lifestyle, and chronic comorbidities, poor subjective memory (HR=1.20, 95%CI: 1.03~1.39) and memory-related diseases (HR=2.59, 95%CI: 1.89~3.56) were significantly associated with an increased risk of stroke. Subgroup analyses indicated that these associations remained stable across different chronic disease strata (all P for interaction >0.05). No statistically significant association was observed between objective memory scores and stroke incidence.
Memory decline is associated with an increased risk of stroke in middle-aged and older adults. Monitoring the early memory status of this population may facilitate the identification of individuals at high risk for stroke.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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