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Association and mediating effects among frailty, depression, and cognitive impairment in community-dwelling older adults, Xinjiang
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Lei XU1, 2, Mulatibieke Tunike2, Xuekelati Saiyare2, Xue BAI2, Hong-mei WANG1, 2
Modern Preventive Medicine | 2026, 53(12) : 2113 - 2116
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Modern Preventive Medicine | 2026, 53(12): 2113-2116
• Epidemiology and Statistical Methods Advance •
Association and mediating effects among frailty, depression, and cognitive impairment in community-dwelling older adults, Xinjiang
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Lei XU1, 2, Mulatibieke Tunike2, Xuekelati Saiyare2, Xue BAI2, Hong-mei WANG1, 2
Affiliations
  • Xinjiang Medical University, Urumqi, Xinjiang Uyghur Autonomous Region 830001, China
Published: 2026-06-25 doi: 10.20043/j.cnki.MPM.202512465
Outline
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Objective

To examine the bidirectional mediating effect of frailty and depression on cognitive impairment.

Methods

Data were obtained from a community-based epidemiological survey conducted in Mulei County, Xinjiang Uygur Autonomous Region, in June 2024. Participants were aged 60 years and older. Information on frailty, depression, and cognitive function was collected. Data analysis included descriptive statistics, correlation analysis, regression analysis, and mediation effect analysis using the SPSS PROCESS Macro.

Results

Compared to those with normal cognitive function, older adults with cognitive dysfunction had a higher mean age and a higher prevalence of depression and frailty, alongside lower body mass index (BMI) and reduced physical activity time(P<0.05). Significant correlations were observed among frailty, depression, and cognitive function(P<0.05). Mediation analysis revealed: Frailty partially mediated the relationship between depression and cognitive function (β= -0.076 9, 95% CI: -0.061 4 to -0.016 2), accounting for 19.22% of the total effect; Depression partially mediated the relationship between frailty and cognitive function (β=-0.203 4, 95%CI: -0.312 6 to -0.107 3), accounting for 28.57% of the total effect.

Conclusion

Frailty and depression act as mutual mediators in predicting cognitive dysfunction in older adults. Interventions targeting both physical frailty and psychological well-being may be effective strategies for the prevention and management of cognitive decline in this population.

Frailty  /  Depression  /  Cognitive impairment  /  Mediating effect
徐磊, 吐尼克·木拉提别克, 赛娅热·雪克拉提, 白雪, 王红梅. 新疆社区老年人群衰弱、抑郁与认知功能障碍的关联及中介效应研究. 现代预防医学, 2026 , 53 (12) : 2113 -2116 . DOI: 10.20043/j.cnki.MPM.202512465
Lei XU, Mulatibieke Tunike, Xuekelati Saiyare, Xue BAI, Hong-mei WANG. Association and mediating effects among frailty, depression, and cognitive impairment in community-dwelling older adults, Xinjiang[J]. Modern Preventive Medicine, 2026 , 53 (12) : 2113 -2116 . DOI: 10.20043/j.cnki.MPM.202512465
Appendix
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Year 2026 volume 53 Issue 12
177
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Article Info
doi: 10.20043/j.cnki.MPM.202512465
  • Receive Date：2025-12-26
  • Online Date：2026-09-28
  • Published：2026-06-25
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  • Received：2025-12-26
Funding
Affiliations
    Xinjiang Medical University, Urumqi, Xinjiang Uyghur Autonomous Region 830001, China
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