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Outline
To explore the association between visceral fat accumulation indicators and gallstone risk in the Dong population of Guizhou.
A total of 6 375 permanent residents aged 30-79 years were enrolled from the Southwest China Natural Population Cohort of Minority Communities. Logistic regression, subgroup analysis and restricted cubic spline analysis were used to examine the associations of metabolic score for visceral fat (METS-VF), lipid accumulation product(LAP), visceral adiposity index (VAI), and waist circumference (WC) with gallstones.
The gallstone detection rate was 10.9% in the Dong population of Guizhou, higher in females (12.2%) than in males (8.4%). Gallstone patients had higher METS-VF, LAP, VAI, and WC. Compared with Q1, Q4 levels of METS-VF (OR=2.206, 95% CI:1.704-2.856), LAP (OR=2.280, 95% CI:1.789-2.905), VAI (OR=1.674, 95% CI:1.323-2.118) and WC (OR=2.046, 95% CI:1.608-2.603) were all positively associated with gallstone risk. Subgroup analyses showed significant associations only in females (P<0.05), with an interaction between gender and METS-VF (P for interaction =0.007). In the age subgroups, VAI was significant only in participants aged <60 years, while the other indicators were significant in both age groups (P<0.05). Medium-to-high levels of all indicators were positively associated with gallstone risk in those consuming glutinous rice or oil tea (P<0.05). Dose-response analyses showed linear associations of METS-VF and WC with gallstone risk, and nonlinear associations of LAP and VAI with gallstone risk.
Visceral fat accumulation indicators are positively associated with gallstone risk in the Dong ethnic population of Guizhou Province. This association exhibits female specificity and is more pronounced among individuals who consume glutinous rice or oil tea. Public health strategies should prioritize visceral fat management in Dong women, utilize these indicators as supplementary tools for early screening, and develop targeted intervention strategies for high-risk populations to reduce the disease burden of gallstones.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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