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To investigate the correlation between the triglyceride glucose product index (TyG) and kidney stones.
Based on the annual health check-up data of employees from a construction company in Hubei in 2022, subjects were divided into kidney stone group (n=854) and non-kidney stone group (n=1 636) according to the presence of kidney stones. Descriptive statistics, chi-square tests, and multivariable logistic regression analyses were employed to assess the correlation between the TyG index and the risk of kidney stones.
A total of 2 490 subjects were included in the study. The kidney stone group had higher levels of age, body mass index (BMI), TyG index, uric acid, total cholesterol, triglycerides, low-density lipoprotein, diastolic blood pressure, and fasting blood glucose compared to the non-kidney stone group (P < 0.05). Multivariable logistic regression analysis indicated that the risk of kidney stones for the 2nd, 3rd, and 4th quartiles of the TyG index was 1.071 times (OR=1.071, 95%CI: 0.822-1.394, P < 0.612), 1.174 times (OR=1.174, 95%CI: 0.886-1.556, P < 0.263), and 1.851 times (OR=1.851, 95%CI: 1.342-2.553, P < 0.001) that of the first quartile, respectively. Higher TyG index levels were associated with an increased risk of kidney stones (χ2=37.146, P < 0.001), indicating that the TyG index was a risk factor for the occurrence of kidney stones with a significant linear relationship. Subgroup analysis revealed that in overweight and obese populations (OR=1.494, 95%CI: 1.245-1.794, P < 0.001) and in populations with hyperlipidemia (OR=2.047, 95%CI: 1.606-2.61,P < 0.001), the TyG index remained positively correlated with the risk of kidney stones (P < 0.05).
A higher TyG index is associated with an increased risk of kidney stones, and early intervention in insulin resistance may help improve or reduce the incidence risk of kidney stones.
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| 科 Family | 属数 Number of genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) | 属 Genus | 种数 Number of species | 占总种数比例 Percentage of total species (%) |
|---|---|---|---|---|---|---|
| 鹅膏菌科Amanitaceae | 2 | 11 | 5.26 | 鹅膏菌属 Amanita | 10 | 4.78 |
| 小菇科 Mycenaceae | 2 | 12 | 5.74 | 丝盖伞属 Inocybe | 5 | 2.39 |
| 多孔菌科 Polyporaceae | 8 | 14 | 6.70 | 蜡蘑属 Laccaria | 5 | 2.39 |
| 红菇科 Russulaceae | 3 | 23 | 11.00 | 小皮伞属 Marasmius | 6 | 2.87 |
| 小菇属 Mycena | 11 | 5.26 | ||||
| 光柄菇属 Pluteus | 5 | 2.39 | ||||
| 红菇属 Russula | 17 | 8.13 | ||||
| 栓菌属 Trametes | 5 | 2.39 |
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