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Mendelian randomization study of the causal relationship between serum micronutrients and hypertension
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Wen-zhu SONG1, 2, 3, Wen-hao SONG4, Xiao-ling LIANG4, Zhen-hua YUE5, Ya-heng LI1, 2
Modern Preventive Medicine | 2024, 51(21) : 3867 - 3872
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Modern Preventive Medicine | 2024, 51(21): 3867-3872
• Epidemiology and Statistical Methods •
Mendelian randomization study of the causal relationship between serum micronutrients and hypertension
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Wen-zhu SONG1, 2, 3, Wen-hao SONG4, Xiao-ling LIANG4, Zhen-hua YUE5, Ya-heng LI1, 2
Affiliations
  • Department of Nephrology, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi 030012, China
Published: 2024-11-10 doi: 10.20043/j.cnki.MPM.202405267
Outline
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Objective

To explore the causal relationship between serum micronutrients and hypertension using Mendelian randomization, thereby promoting the prevention and health management of hypertension.

Methods

Fourteen serum micronutrients were selected as exposure factors, with hypertension as the outcome. Two-sample Mendelian randomization analyses were conducted based on genome-wide association study data from European populations, followed by multivariable Mendelian randomization analyses to identify variables that may have a causal relationship with the outcome, determining the independent effects of each exposure factor on the outcome.

Results

Univariate Mendelian randomization analysis indicated a positive causal effect of elevated copper levels on the incidence of hypertension (P<0.05). Multivariable Mendelian randomization showed that the causal relationship between copper and hypertension remained significant after controlling for potassium and vitamin B6 (OR=1.028, 95%CI: 1.009-1.047, P<0.05).

Conclusion

There is a causal relationship between elevated copper levels and hypertension. However, the findings of this study require validation through randomized controlled trials.

Micronutrients  /  Hypertension  /  Mendelian randomization  /  Risk factors  /  Causal effect
Wen-zhu SONG, Wen-hao SONG, Xiao-ling LIANG, Zhen-hua YUE, Ya-heng LI. Mendelian randomization study of the causal relationship between serum micronutrients and hypertension[J]. Modern Preventive Medicine, 2024 , 51 (21) : 3867 -3872 . DOI: 10.20043/j.cnki.MPM.202405267
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Article Info
doi: 10.20043/j.cnki.MPM.202405267
  • Receive Date：2024-05-18
  • Online Date：2026-03-20
  • Published：2024-11-10
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  • Received：2024-05-18
Funding
Affiliations
    Department of Nephrology, Shanxi Provincial People’s Hospital, Taiyuan, Shanxi 030012, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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